Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMH0ROP)

Drug Name
Maltose Drug Info
Synonyms
beta-maltose; Maltobiose; Maltose, pure; Advanctose 100; 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranose; Cextromaltose; Maltodiose; Finetose; Sunmalt; Malt sugar; Finetose F; Sunmalt S; UNII-R4B6462NGR; D-Glucose, 4-O-alpha-D-glucopyranosyl-; AI3-09089; EINECS 200-716-5; BRN 0093798; 4-O-alpha-D-Glucopyranosyl-D-glucose; R4B6462NGR; 4-(alpha-D-Glucosido)-D-glucose; CHEBI:18147; beta-D-Cellobiose; GUBGYTABKSRVRQ-QUYVBRFLSA-N; beta-D-glucopyranose, 4-O-alpha-D-glucopyranosyl-
Cross-matching ID
PubChem CID
6255
ChEBI ID
CHEBI:18147
CAS Number
CAS 133-99-3
TTD Drug ID
DMH0ROP
INTEDE Drug ID
DR2110

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Alpha-glucosidase (GLA) TTHCF4J LYAG_HUMAN; GANAB_HUMAN; GANC_HUMAN Inhibitor [1]
Intestinal maltase-glucoamylase (MGAM) TTXWASR MGA_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Sucrase-isomaltase intestinal (SI) DE5EO4Y SUIS_HUMAN Phase 1/2 [2]
Maltose phosphorylase (malP) DE7NXHG Q5FI04_LACAC Phase 1/2 [3]
Cellobiose 2-epimerase (CE) DERDXAF CEEP_RUMAL Phase 1/2 [4]
Fructokinase (scrK) DEBW1FU SCRK_FUSMR Phase 1/2 [5] , [6]
Cellobiose 2-epimerase (CE) DEGLW18 A0A173SS24_9FIRM Phase 1/2 [4]
Cellobiose 2-epimerase (CE) DENTGJO A0A173Z970_9FIRM Phase 1/2 [4]
Cellobiose 2-epimerase (CE) DE4XLDR A0A174ZCD1_9FIRM Phase 1/2 [4]
Cellobiose 2-epimerase (CE) DEGBVKJ A9KK53_LACP7 Phase 1/2 [4]
Cellobiose 2-epimerase (CE) DEDY9F6 CEEP_EUBCE Phase 1/2 [4]
Alpha-glucosidase (aglA) DEST6E5 A0A173ZA10_9FIRM Phase 1/2 [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sucrase-isomaltase intestinal (SI) DME SI 1.585 8.263 0 10.989
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Intestinal maltase-glucoamylase (MGAM) DTT MGAM 4.59E-01 -0.02 -0.24
Sucrase-isomaltase intestinal (SI) DME SI 5.34E-01 -5.94E-03 -1.31E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
2 Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70.
3 Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase. Protein Eng Des Sel. 2010 Oct;23(10):781-7.
4 Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.
5 Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
6 Clinical Fusobacterium mortiferum isolates cluster with undifferentiated Clostridium rectum species based on 16S rRNA gene phylogenetic analysis. Ann Clin Lab Sci. 2016 May;46(3):279-81.
7 Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49.