Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVFB93)

Drug Name

Nitrate Drug Info

Synonyms

nitrate; NITRATE ION; 14797-55-8; Nitrate(1-); UNII-T93E9Y2844; Nitrate(6CI,7CI,8CI,9CI); UN3218; CHEMBL186200; NO3-; Nitrates; CHEBI:17632; T93E9Y2844; NO3; trioxidonitrate; trioxonitrate; nitrooxidane; trioxonitrate(V); trioxonitrate(1-); trioxidonitrate(1-); AC1L1ADK; Nitrates, inorganic, n.o.s.; CTK0H4660; BDBM26988; NHNBFGGVMKEFGY-UHFFFAOYSA-N; 84145-82-4 (Parent); NO3(-); AKOS015904030; MCULE-5142506228; [NO3](-); Nitrates, inorganic, aqueous solution, n.o.s.; I14-18318; Nitrates, inorganic, n.o.s. [UN1447] [Oxidizer]; Nitrates, in

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 943
ChEBI ID: CHEBI:17632
TTD Drug ID: DMVFB93
VARIDT Drug ID: DR00009

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
Anion exchange transporter (SLC26A7)	DTOTME4	S26A7_HUMAN	Phase 4	[2]
Sodium/iodide cotransporter (SLC5A5)	DTZAH46	SC5A5_HUMAN	Phase 4	[3]
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTWLACT	S17A5_HUMAN	Phase 4	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Sodium/iodide cotransporter (SLC5A5)	DTP	NIS	7.754	7.029	7.351	6.322
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTP	AST	7.618	7.419	7.95	7.127

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Sodium/iodide cotransporter (SLC5A5)	DTP	NIS	7.70E-16	-2.18E-01	-5.48E-01
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTP	AST	4.66E-05	-1.66E-01	-4.42E-01
Anion exchange transporter (SLC26A7)	DTP	SLC26A7	3.16E-11	-3.62E-01	-7.55E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.
2	The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6)
3	The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.21.5.1)
4	Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9.