Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW8S2D)

Drug Name

N-(4-cyanophenyl)sulfamide Drug Info

Synonyms

N-(4-cyanophenyl)sulfamide; 164648-70-8; (4-cyanophenyl)sulfamide; CHEMBL166340; N-(4-cyanophenyl)aminosulfonamide; N-(4-cyanophenyl)sulfuric diamide; EN300-34005; AC1Q55HF; Sulfamide, (4-cyanophenyl)-; SCHEMBL1646278; Sulfamide, N-(4-cyanophenyl)-; CTK0E5869; DTXSID50597031; MolPort-004-336-840; 4-(Aminosulfonylamino)benzonitrile; ZINC13013704; BDBM50124179; AKOS000176530; FCH5272297; BBV-070788; NE46233; MCULE-1558116315; NCGC00338522-01; KB-299386; 79489-EP2305695A2; 79489-EP2305697A2; AB01330899-02; 79489-EP2305698A2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 18975977
CAS Number: CAS 164648-70-8
TTD Drug ID: DMW8S2D

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XII (CA-XII)	DTT	CA12	6.015	9.06	10.222	5.773
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase XII (CA-XII)	DTT	CA12	3.29E-21	1.27	1.02
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.