Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZDN4W)

Drug Name
L-alanine Drug Info
Synonyms
ALA; Alaninum; LPG; Polyalanine; A-Alanine; A-Aminopropionic acid; Alanina [DCIT,Spanish]; Alanine (USP); L-A-Aminopropionicacid; L-Alanine (9CI); L-Alanine (JAN); L-Alanine, homopolymer; L-Alanine, labeled with tritium; L-a-Alanine; L-a-Aminopropionic acid; Poly-DL-alanine; L-Alanine, labeled with carbon-14; Alanine, L-(7CI,8CI); F4F207FF-8FF8-4789-99A1-147AE0A36673; L-Alanine, N-coco alkyl derivs.; Propanoic acid, 2-amino-, (S); (C14)L-Alanine; (S)-2-Aminopropionic acid; 14C-L-Alanine
Indication
Disease Entry ICD 11 Status REF
Dietary shortage 5B5K Approved [1] , [2] , [3]
Glioma 2A00.0 Approved [1] , [2] , [3]
Therapeutic Class
Dietary supplement
Cross-matching ID
PubChem CID
5950
ChEBI ID
CHEBI:16977
CAS Number
CAS 56-41-7
TTD Drug ID
DMZDN4W
VARIDT Drug ID
DR00142

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA transaminase (ABAT) TTT2LD9 GABT_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DTKWJH3 S38A3_HUMAN Approved [5]
Sodium-coupled neutral amino acid transporter 5 (SLC38A5) DTLX28N S38A5_HUMAN Approved [5]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4) DTPJBD5 S38A4_HUMAN Approved [5]
Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DTTWL58 S38A2_HUMAN Approved [5]
Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DTD815L S38A1_HUMAN Approved [5]
L-type amino acid transporter 2 (SLC7A8) DTJF3DX LAT2_HUMAN Approved [6]
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTC54PX SATT_HUMAN Approved [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
GABA transaminase (ABAT) DTT ABAT 9.337 6.208 6.982 6.764
Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DTP SNAT2 10.939 9.504 9.057 8.423
Sodium-coupled neutral amino acid transporter 4 (SLC38A4) DTP SNAT4 8.667 3.907 3.7 1.138
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DTP SNAT3 8.347 5.545 3.722 4.524
L-type amino acid transporter 2 (SLC7A8) DTP LAT2 5.741 6.763 7.117 6.583
Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DTP SNAT1 6.135 8.276 7.095 8.018
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTP ASCT1 6.684 6.087 6.002 6.201
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Brainstem tissue
The Studied Disease Glioma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
GABA transaminase (ABAT) DTT ABAT 5.15E-01 0.74 0.76
GABA transaminase (ABAT) DTT ABAT 1.37E-01 0.59 0.46
Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DTP SNAT2 1.60E-02 -2.27E-01 -8.32E-01
Sodium-coupled neutral amino acid transporter 4 (SLC38A4) DTP SNAT4 1.91E-02 -1.22E-01 -7.11E-01
Sodium-coupled neutral amino acid transporter 5 (SLC38A5) DTP SNAT5 9.89E-03 -2.82E-01 -9.82E-01
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DTP SNAT3 4.44E-01 -1.01E-01 -3.19E-01
L-type amino acid transporter 2 (SLC7A8) DTP LAT2 6.59E-01 -2.37E-01 -3.24E-01
Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DTP SNAT1 4.12E-05 1.23E+00 2.07E+00
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTP ASCT1 6.61E-01 -1.27E-02 -3.00E-02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 720).
2 Drug information of L-Alanine, Health Canada, 2008. (drugid: 7638)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
5 Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.
6 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20)
7 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.