Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0CSH8)

• Drug Name: 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole Drug Info
• Synonyms: 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE; CHEMBL383990; 3-(1H-1,3-benzodiazol-2-yl)-2H-indazole; 2-(2H-indazol-3-yl)-1H-1,3-benzodiazole; IDZ; 1097816-83-5; Indazole Compound 2; 2c3l; AC1Q4XAS; AC1NS1P1; SCHEMBL311148; BDBM16590; 3-benzimidazol-2-yl-1h-indazole; JTKFRFMSUBOCIQ-UHFFFAOYSA-N; MolPort-016-542-829; ZINC14961821; AKOS009356321; NE25942; MCULE-6782886882; DB07959; 2-(1H-indazol-3-yl)-1H-benzimidazole; 3-(1H-benzoimidazol-2-yl)-1H-indazole; 2-(1H-Indazole-3-yl)-1H-benzoimidazole; EN300-70692

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

• Cross-matching ID:
  PubChem CID: 135464491
  TTD Drug ID: DM0CSH8

Molecule-Related Drug Atlas

Drug(s) Targeting Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[3]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[4]
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[5]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[7]
Rosiglitazone + metformin	DMPIDXT	Diabetic complication	5A2Y	Phase 3	[8]
BGJ398	DMNKBEC	Cholangiocarcinoma	2C12.10	Phase 3	[9]
ARQ-087	DM02BVQ	Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[10]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[11]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]

Drug(s) Targeting Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[13]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[14]
Becaplermin	DM1R5X4	Diabetic complication	5A2Y	Approved	[15]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[18]
SNN-0031	DM2X3BR	Brain injury	NA07.Z	Phase 1/2	[19]
TAK-593	DMNFZOT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[20]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[21]

Drug(s) Targeting Checkpoint kinase-1 (CHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2603618	DMCXRZF	Pancreatic cancer	2C10	Phase 2	[22]
UCN-01	DMUNJZB	Non-small-cell lung cancer	2C25.Y	Phase 2	[23]
SCH-900776	DM67EMK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]
LY2606368	DM4XMF7	Ovarian cancer	2C73	Phase 2	[12]
LY2880070	DMADEHZ	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[25]
RG7741	DMK6P9J	Lymphoma	2A80-2A86	Phase 1	[26]
GDC-0425	DMDZ26X	Lymphoma	2A80-2A86	Phase 1	[27]
AZD7762	DM1FW0C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[28]
MK-8776	DMAS1RB	Hodgkin lymphoma	2B30	Phase 1	[29]
Diamidothiazole derivative 1	DM02V5Q	N. A.	N. A.	Patented	[30]

Drug(s) Targeting VEGFR1 messenger RNA (VEGFR1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[31]
VATALANIB	DMY0UEQ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[32]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[18]
Sirna-027	DMZTQD8	Exudative age-related macular degeneration	9B78.3Z	Phase 1/2	[33]
PMID22765894C8h	DMH5RFU	Discovery agent	N.A.	Investigative	[34]
AAL-993	DM35RFH	Discovery agent	N.A.	Investigative	[32]
PMID17935989C25	DML8ZBR	Discovery agent	N.A.	Investigative	[35]
2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile	DMX6QMT	Discovery agent	N.A.	Investigative	[36]
4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide	DMI3OR9	Discovery agent	N.A.	Investigative	[37]
(2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine	DMQWD75	Discovery agent	N.A.	Investigative	[36]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[13]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[3]
Regorafenib	DMHSY1I	Metastatic colorectal cancer	2B91	Approved	[38]
Sunitinib	DMCBJSR	Gastrointestinal cancer	2C11	Approved	[39]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[40]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[8]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[41]
Cabozantinib	DMIYDT4	Thyroid cancer	2D10	Approved	[42]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[43]
Lenvatinib	DMB1IU4	Thyroid cancer	2D10	Approved	[44]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Checkpoint kinase-1 (CHK1)	TTTU902	CHK1_HUMAN	Inhibitor	[1]
Fibroblast growth factor receptor 1 (FGFR1)	TTRLW2X	FGFR1_HUMAN	Inhibitor	[2]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[2]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[2]
VEGFR1 messenger RNA (VEGFR1 mRNA)	TT1VAUK	VGFR1_HUMAN	Inhibitor	[2]

References

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