General Information of Drug (ID: DM1LDIP)

Drug Name
EcoNail Drug Info
Synonyms Econazole/SEPA
Indication
Disease Entry ICD 11 Status REF
Fungal infection 1F29-1F2F Phase 2 [1]
Cross-matching ID
PubChem CID
68589
CAS Number
CAS 24169-02-6
TTD Drug ID
DM1LDIP
ACDINA Drug ID
D01028

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [3]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [3]
Posaconazole DMUL5EW Aspergillosis 1F20 Approved [4]
Ketoconazole DMPZI3Q Blastomycosis 1F22 Approved [5]
Miconazole DMPMYE8 Cutaneous candidiasis 1F23.14 Approved [3]
Oxiconazole DME7KRM Tinea corporis 1F28.Y Approved [6]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [3]
Terconazole DMJ13KI Candidiasis 1F23 Approved [7]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [8]
Tioconazole DMNYPGS Onychomycosis EE12.1 Approved [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00385502) A Trial of the Safety and Efficacy of EcoNail in the Treatment of Fungus Infections of the Great Toenail. U.S. National Institutes of Health.
2 Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity. Mycoses. 2006;49 Suppl 1:2-6.
5 Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
6 Antifungal agents: mechanisms of action. Trends Microbiol. 2003 Jun;11(6):272-9.
7 Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9.
8 Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7.
9 Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6.