Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM25EDB)

Drug Name

PRT-060096 Drug Info

Synonyms

PRT-060280; PRT-060288; PRT-060289; PRT-060392; PRT-060592; PRT-060674; PRT-061105; PRT-061106; PRT-061110; PRT-061171; Non-sulfonylurea P2Y12 antagonists (cardiovascular disease); Non-sulfonylurea P2Y12 antagonists (cardiovascular disease), Portola

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DM25EDB

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting P2Y purinoceptor 12 (P2RY12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[2]
Prasugrel	DM7MT6E	Acute coronary syndrome	BA41	Approved	[3]
Brilinta	DMBR01X	Acute coronary syndrome	BA41	Approved	[4]
Cangrelor	DM8JRH0	Thrombosis	DB61-GB90	Approved	[1]
INS-50589	DMKZUVC	Cardiovascular disease	BA00-BE2Z	Phase 2	[5]
Elinogrel	DMA4BRV	Myocardial infarction	BA41-BA43	Phase 1	[6]
ARL-67085	DMY5IM2	Thrombosis	DB61-GB90	Phase 1	[7]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[2]
2MeSADP	DMGADQ1	Discovery agent	N.A.	Investigative	[8]
2MeSAMP	DMBO2DC	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 12 (P2RY12)	TTZ1DT0	P2Y12_HUMAN	Antagonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328).
2	P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22.
3	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
4	Clinical pipeline report, company report or official report of AstraZeneca (2009).
5	Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589. Platelets. 2007 Aug;18(5):346-56.
6	Elinogrel, a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events. Curr Opin Investig Drugs. 2010 Mar;11(3):340-8.
7	Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206.
8	Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9.