Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM26IH8)

Drug Name

S-297995 Drug Info

Synonyms

NALDEMEDINE; UNII-03KSI6WLXH; 03KSI6WLXH; S-297,995; 916072-89-4; Naldemedine [USAN:INN]; Naldemedine (USAN/INN); S 297995; SCHEMBL9880572; GTPL9150; CHEMBL2105755; AKOS032945757; DB11691; Morphinan-7-carboxamide, 17-(cyclopropylmethyl)-6,7-didehydro-4,5-epoxy-3,6,14- trihydroxy-N-(1-methyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl)-,(5alpha)-; J3.573.009E; D10188

Indication

Disease Entry	ICD 11	Status	REF
Opioid dependence	6C43.2Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 54732242
CAS Number: CAS 916072-89-4
TTD Drug ID: DM26IH8
ACDINA Drug ID: D00453

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Opioid receptor (OPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methadone	DMTW6IU	Dry cough	MD12	Approved	[2]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[3]
Oxymorphone	DM65AGJ	Pain	MG30-MG3Z	Approved	[4]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[5]
Sufentanil	DMU7YEL	Analgesia	MB40.8	Approved	[6]
Naltrexone	DMUL45H	Alcohol dependence	6C40.2	Approved	[7]
Levorphanol	DMGS80V	Pain	MG30-MG3Z	Approved	[8]
Pentazocine	DM1XBHS	Pain	MG30-MG3Z	Approved	[9]
Nalmefene	DM4YWCZ	Opioid dependence	6C43.2Z	Approved	[10]
Tilidine	DMJW0VS	Pain	MG30-MG3Z	Approved	[11]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor (OPR)	TTN4QDT	NOUNIPROTAC	Antagonist	[1]

------------------------------------------------------------------------------------

References

1	Clinical pipeline report, company report or official report of Shionogi (2011).
2	Methadone treatment and its dangers. Medicina (Kaunas). 2009;45(5):419-25.
3	The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene. Pharmacol Toxicol. 1996 Aug;79(2):103-4.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7094).
5	Retrospective diagnosis of an adverse drug reaction in a breastfed neonate: liquid chromatography-tandem mass spectrometry quantification of dextropropoxyphene and norpropoxyphene in newborn and maternal hair. J Anal Toxicol. 2008 Nov-Dec;39(9):787-9.
6	mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2. J Neurochem. 2009 Aug;110(4):1288-96.
7	An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry. 2008 Feb;65(2):135-44.
8	Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. J Pharmacol Exp Ther. 2004 May;309(2):515-22.
9	Functional characterization of a sigma receptor and its gene expression by haloperidol. Nippon Yakurigaku Zasshi. 1999 Jul;114(1):61-8.
10	Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospin... J Pharmacol Exp Ther. 2009 Feb;328(2):588-97.
11	Actions of tilidine and nortilidine on cloned opioid receptors. Eur J Pharmacol. 2005 Jan 4;506(3):205-8.