Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2MPWC)

• Drug Name: 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol Drug Info
• Synonyms: CHEMBL388123; 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9863568
  TTD Drug ID: DM2MPWC

Molecule-Related Drug Atlas

Drug(s) Targeting Opioid receptor mu (MOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[2]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[3]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[4]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[5]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[6]
Alfentanil	DMVO0UB	Anaesthesia	9A78.6	Approved	[7]
Naloxegol	DML0B41	Opioid-induced constipation	DB32.1	Approved	[8]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[9]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[10]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[11]

Drug(s) Targeting Nociceptin receptor (OPRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[12]
SER-100	DMDW5ZC	Heart failure	BD10-BD13	Phase 2	[13]
BTRX-246040	DMA9238	Major depressive disorder	6A70.3	Phase 2	[14]
LY-2940094	DMB5L6Q	Major depressive disorder	6A70.3	Phase 2	[15]
NOCICEPTIN	DMUPA7C	Headache	8A80-8A84	Phase 1	[16]
JTC-801	DMV3UN4	Pain	MG30-MG3Z	Discontinued in Phase 2	[17]
ND1251	DMMLESX	Depression	6A70-6A7Z	Discontinued in Phase 1	[18]
ATI-17000	DMZJVR5	Irritable bowel syndrome	DD91.0	Preclinical	[19]
4-phenyl-1-(1-phenylbutyl)piperidin-4-ol	DMVCIJB	Discovery agent	N.A.	Investigative	[1]
1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol	DMLYO8P	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Opioid receptor delta (OPRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Codeine	DMJX6ZG	Allergic rhinitis	CA08.0	Approved	[20]
Hydromorphone	DMHP21E	Back pain	ME84.Z	Approved	[21]
Loperamide	DMOJZQ9	Diarrhea	ME05.1	Approved	[22]
Eluxadoline	DMYZ0P1	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[9]
Oxycodone	DMXLKHV	Osteoarthritis	FA00-FA05	Approved	[23]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[20]
Carfentanil	DM7ADGX	N. A.	N. A.	Phase 2	[24]
Met-enkephalin	DMSZFTP	Pain	MG30-MG3Z	Phase 2	[25]
AZD-2327	DM8FZOG	Anxiety disorder	6B00-6B0Z	Phase 2	[26]
ADL-5747	DMMUPTN	Pain	MG30-MG3Z	Phase 2	[27]

Drug(s) Targeting Opioid receptor kappa (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nalbuphine	DMOSQGU	Pain	MG30-MG3Z	Approved	[28]
Nalfurafine hcl	DMA9DHW	Uremic pruritus	EC90.10	Approved	[10]
CHLOROXINE	DMFZBMQ	Erythema	ME64.0	Approved	[29]
Difelikefalin	DMHZBEO	Pruritus	EC90	Approved	[30]
Dezocine	DMJDB0Y	Pain	MG30-MG3Z	Approved	[31]
Asimadoline	DMND3AB	Diarrhea-predominant irritable bowel syndrome	DD91.01	Phase 3	[32]
JNJ 67953964	DMJ8Y5N	Major depressive disorder	6A70.3	Phase 3	[33]
PHN-131	DM1SV8I	Pain	MG30-MG3Z	Phase 2/3	[34]
CR-845	DMJYTUQ	Pain	MG30-MG3Z	Phase 2/3	[35]
Carfentanil	DM7ADGX	N. A.	N. A.	Phase 2	[24]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nociceptin receptor (OPRL1)	TTNT7K8	OPRX_HUMAN	Inhibitor	[1]
Opioid receptor delta (OPRD1)	TT27RFC	OPRD_HUMAN	Inhibitor	[1]
Opioid receptor kappa (OPRK1)	TTQW87Y	OPRK_HUMAN	Inhibitor	[1]
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Inhibitor	[1]

References

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