Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2OZBL)

Drug Name

Howiinol A (GHM-10) Drug Info

Synonyms

Howiinol A; (+)-Howiinol A; AC1O5TEF; CHEMBL1170578; D-xylo-Hept-2-enonic acid, 2,3-dideoxy-7-C-phenyl-, delta-lactone, 7-((2E)-3-phenyl-2-propenoate), (7R)-; 190848-69-2; [(1R,2R)-2-hydroxy-2-[(2R,3S)-3-hydroxy-6-oxo-2,3-dihydropyran-2-yl]-1-phenylethyl] (E)-3-phenylprop-2-enoate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6440329
CAS Number: CAS 190848-69-2
TTD Drug ID: DM2OZBL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[2]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[3]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[4]
Idarubicin	DMM0XGL	Acute myelogenous leukaemia	2A41	Approved	[2]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[5]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[2]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[6]
Enoxacin	DMYTE6L	Acute gonococcal cervicitis		Approved	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Inhibitor	[1]

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References

1	Anticancer effect of Howiinol A and its mechanism of action. J Asian Nat Prod Res. 1999;2(1):1-19.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
4	Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
5	Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
6	Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
7	Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.