Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM35YFC)

Drug Name

MS-1819 Drug Info

Synonyms

Recombinant lipase (exocrine pancreatic insufficiency), Laboratoires Mayoly Spindler

Indication

Disease Entry	ICD 11	Status	REF
Exocrine pancreatic insufficiency	DC35.1	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Pancreatic triacylglycerol lipase (PNLIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Orlistat	DMRJSP8	Obesity	5B81	Approved	[3]
Dalbavancin	DMGMNH3	Bacterial infection	1A00-1C4Z	Approved	[4]
Pancrecarb	DMOML9Q	Pancreatic malfunction	DC30-DC3Z	NDA filed	[5]
Liprotamase	DMNF4UH	Cystic fibrosis	CA25	Phase 3	[6]
AZM-131	DMLCSRF	Obesity	5B81	Terminated	[7]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[8]
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DMY6FUD	Discovery agent	N.A.	Investigative	[8]
B-Nonylglucoside	DM48VJR	Discovery agent	N.A.	Investigative	[9]
METHOXYUNDECYLPHOSPHINIC ACID	DMY0O7X	Discovery agent	N.A.	Investigative	[9]
Daio-Orengedokuto (DOT)	DM3M652	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pancreatic triacylglycerol lipase (PNLIP)	TTXMY0J	LIPP_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030334)
2	Clinical pipeline report, company report or official report of AzurRx.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Pfizer. Product Development Pipeline. March 31 2009.
5	Clinical pipeline report, company report or official report of Digestive Care.
6	Clinical pipeline report, company report or official report of Anthera Pharmaceuticals.
7	US patent application no. 7217,697, Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
10	Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase. Biol Pharm Bull. 2002 Nov;25(11):1442-5.