Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM37C25)

Drug Name
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid Drug Info
Synonyms CHEMBL573935; [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44479701
TTD Drug ID
DM37C25

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Matrix metalloproteinase-12 (MMP-12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [2]
FP-025 DMH1NXO Asthma CA23 Phase 1 [3]
PMID29130358-Compound-Figure17(12) DMML4PA N. A. N. A. Patented [4]
PMID29130358-Compound-Figure17(10) DMVA15O N. A. N. A. Patented [4]
PMID29130358-Compound-Figure17(11) DMSZA9L N. A. N. A. Patented [4]
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [5]
AZD1236 DML3RSF Chronic obstructive pulmonary disease CA22 Discontinued in Phase 2 [6]
V85546 DMLFMSY Inflammation 1A00-CA43.1 Discontinued in Phase 1 [7]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [8]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-8 (MMP-8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CIPEMASTAT DM803GL Rheumatoid arthritis FA20 Phase 3 [9]
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [10]
SC-44463 DMBPNKT N. A. N. A. Terminated [11]
BB-1101 DM7GH5Z Multiple sclerosis 8A40 Terminated [12]
MMI270 DM38N2K Discovery agent N.A. Investigative [13]
IK-862 DMJA4UE Discovery agent N.A. Investigative [14]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [1]
SL422 DM3I2US Discovery agent N.A. Investigative [15]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [1]
Ro-37-9790 DM83QMZ Discovery agent N.A. Investigative [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-13 (MMP-13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [17]
Apratastat DM8W4N9 Rheumatoid arthritis FA20 Phase 2 [18]
PMID17935984C1 DMO1IHL Pain MG30-MG3Z Clinical trial [19]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [4]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [4]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [4]
PMID29130358-Compound-Figure18(14) DM7WXJ9 N. A. N. A. Patented [4]
PMID29130358-Compound-Figure16(9c) DM0ZRI9 N. A. N. A. Patented [4]
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [20]
RS-130830 DMOTANY Hepatitis C virus infection 1E51.1 Discontinued in Phase 2 [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-9 (MMP-9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [22]
DP-b99 DM97S10 Stroke 8B20 Phase 3 [23]
GS-5745 DMP8MDW Gastric adenocarcinoma 2B72 Phase 3 [24]
Andecaliximab DMLDB1X Gastric adenocarcinoma 2B72 Phase 3 [25]
BLZ-100 DMFKA4G Glioma 2A00.0 Phase 1/2 [26]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [2]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [4]
PMID29130358-Compound-Figure17(12) DMML4PA N. A. N. A. Patented [4]
PMID29130358-Compound-Figure17(10) DMVA15O N. A. N. A. Patented [4]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-14 (MMP-14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [27]
BT1718 DMTXBUV Solid tumour/cancer 2A00-2F9Z Phase 1/2a [28]
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [29]
MMI270 DM38N2K Discovery agent N.A. Investigative [30]
IK-862 DMJA4UE Discovery agent N.A. Investigative [14]
SR-973 DMU48OD Discovery agent N.A. Investigative [31]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [1]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [1]
UK-356618 DM02FGH Discovery agent N.A. Investigative [32]
PMID23631440C29e DMM92IB Discovery agent N.A. Investigative [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-2 (MMP-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prinomastat DM9HOKG Lung cancer 2C25.0 Approved [34]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [27]
Marimastat DM6V34C Pancreatic cancer 2C10 Phase 3 [35]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [2]
Metastat DMTQ4PN Acne vulgaris ED80 Phase 1 [36]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [4]
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [4]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [4]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [4]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-21 (MMP-21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [5]
IK-862 DMJA4UE Discovery agent N.A. Investigative [14]
SR-973 DMU48OD Discovery agent N.A. Investigative [31]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [1]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [1]
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid DMQDPHT Discovery agent N.A. Investigative [5]
N-hydroxy-2,3-bis(phenylsulfonamido)propanamide DMZWIVJ Discovery agent N.A. Investigative [37]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-12 (MMP-12) TTXZ0KQ MMP12_HUMAN Inhibitor [1]
Matrix metalloproteinase-13 (MMP-13) TTHY57M MMP13_HUMAN Inhibitor [1]
Matrix metalloproteinase-14 (MMP-14) TTJ4QE7 MMP14_HUMAN Inhibitor [1]
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [1]
Matrix metalloproteinase-21 (MMP-21) TTYRF5E MMP21_HUMAN Inhibitor [1]
Matrix metalloproteinase-8 (MMP-8) TTGA1IV MMP8_HUMAN Inhibitor [1]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [1]

References

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23 DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity. PLoS One. 2014 Jun 11;9(6):e99789.
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25 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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30 Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74.
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