Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM37FKA)

• Drug Name: Primovist Drug Info
• Synonyms: Eovist; Primovist; gadoxate disodium; AC1L9OPS; gadolinium ethoxybenzyl-DTPA; MOLI000482; 2-[[2-[bis(carboxymethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid; gadolinium(3+)

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Phase 4	[1]

• Cross-matching ID:
  PubChem CID: 450096
  TTD Drug ID: DM37FKA
  VARIDT Drug ID: DR01617

Molecule-Related Drug Atlas

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[4]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[2]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[5]
Pravastatin	DM6A0X7	Hypercholesterolaemia	5C80.0	Approved	[7]
Mycophenolate mofetil	DMPQAGE	Organ transplant rejection	NE84	Approved	[8]
Atorvastatin	DMF28YC	Cardiovascular disease	BA00-BE2Z	Approved	[9]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[10]
Pitavastatin calcium	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[7]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[11]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[12]
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[13]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[5]
Pravastatin	DM6A0X7	Hypercholesterolaemia	5C80.0	Approved	[14]
Mycophenolate mofetil	DMPQAGE	Organ transplant rejection	NE84	Approved	[8]
Atorvastatin	DMF28YC	Cardiovascular disease	BA00-BE2Z	Approved	[10]
Erythromycin	DM4K7GQ	Bacterial infection	1A00-1C4Z	Approved	[15]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[10]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[2]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[3]

References

• [1] ClinicalTrials.gov (NCT03215355) Improving CBCT for Liver IG-SBRT Using Gadoxetate Disodium
• [2] Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
• [3] Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 2010 Jul;38(7):1024-8.
• [4] Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
• [5] Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
• [6] Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
• [7] The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
• [8] Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
• [9] Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52.
• [10] FDA Drug Development and Drug Interactions
• [11] LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
• [12] Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
• [13] Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
• [14] Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
• [15] Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705.