Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3PJSE)

Drug Name

TP-271 Drug Info

Synonyms

UNII-Y6IUM7395Q; Y6IUM7395Q; 1207284-17-0; (S)-N-((5aR,6aS,7S,10aS)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,8,10a,11-tetrahydroxy-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracen-2-yl)-1-methylpyrrolidine-2-carboxamide; (2S)-N-((5aR,6aS,7S,10aR)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl)-1-methylpyrrolidine-2-carboxamide; (2S)-N-[(5aR,6aS,7S,10aR)-9-carbamoyl-7-(dimethylamino)-4-fluoro-1,10,10a,12-tetrahydroxy-8,11-dioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-1-methylpyrrolidine-2-carboxamide; CHEMBL2057236; SCHEMBL13397803; GTPL11013; TP271; DB15040

Indication

Disease Entry	ICD 11	Status	REF
Pneumonia	CA40	Phase 1	[1]
Respiratory tract infection	CA45	Phase 1	[2]

Cross-matching ID

PubChem CID: 54726193
CAS Number: CAS 1207284-17-0
TTD Drug ID: DM3PJSE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[4]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[5]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[6]
TP-434	DM5A31S	Intra-abdominal infection	1A40	Approved	[7]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[5]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[8]
Sarecycline	DMLZNIQ	Acne vulgaris	ED80	Approved	[9]
ME1100	DM39PSZ	Bacterial pneumonia	CA40.0	Phase 1	[10]
TP-6076	DM5RIT8	Enterobacteriaceae infection	MG50.C	Phase 1	[11]
TP 6076	DMD0NA1	Multidrug resistant infection	MG51	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA)	TTOVFH2	NOUNIPROTAC	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT02724085) A Phase 1 Study to Assess the Safety, Tolerability and PK of IV TP-271. U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT03234738) A Phase 1 Safety and PK Study of IV TP-271. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.
4	The antibiotic Furvina targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Mechanism of action of aminoglycoside antibiotics.Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits.Eur J Biochem.1979 Dec;102(1):73-81.
7	The antibiotic arms race: current and emerging therapy for Klebsiella pneumoniae carbapenemase (KPC) - producing bacteria.Expert Opin Pharmacother. 2018 Oct 22:1-13.
8	Omadacycline Enters the Ring: A New Antimicrobial Contender.Pharmacotherapy. 2018 Dec;38(12):1194-1204.
9	Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01297-18.
10	ClinicalTrials.gov (NCT01961830) Intrapulmonary Pharmacokinetics of ME1100 in Healthy Volunteers. U.S. National Institutes of Health.
11	Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.