Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4ME02)

Drug Name
Ticarcillin Drug Info
Synonyms
TIPC; Ticarcilina; Ticarcilline; Ticarcillinum; Ticarcillin Supplement; Ticillin [veterinary]; BRL-2288; Ticarcilina[INN-Spanish]; Ticarcillin (INN); Ticarcillin [INN:BAN]; Ticarcilline [INN-French]; Ticarcillinum [INN-Latin]; Ticillin [veterinary] (TN); Timentin (TN); A-carboxy-3-thienylmethylpenicillin; Alpha-carboxy-3-thienylmethylpenicillin; (2S,5R,6R)-6-[[(2R)-3-hydroxy-3-oxo-2-thiophen-3-ylpropanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6beta-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-2,2-dimethylpenam-3alpha-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Aspiration pneumonia Approved [1]
Bacteremia 1A73 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Lung abscess Approved [1]
Pleural empyema Approved [1]
Salpingitis Approved [1]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Urinary tract infection GC08 Approved [1]
Pelvic inflammatory disease GA05 Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
36921
ChEBI ID
CHEBI:9587
CAS Number
CAS 34787-01-4
TTD Drug ID
DM4ME02
INTEDE Drug ID
DR2409

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ampicillin DMHWE7P Acute epiglottitis Approved [7]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [8]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [9]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [10]
Meropenem DM62UHC Bacterial infection 1A00-1C4Z Approved [9]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [11]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [12]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [13]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [14]
Piperacillin DMTBKF3 Acute gonococcal cervicitis Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Beta-lactamase (blaB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [16]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [5]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [5]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [5]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [5]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [5]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [17]
Carbenicillin DMLEDNK Infection of the upper and lower urinary tract GC08 Approved [6]
Cefoxitin DMY8NC4 Acute gonococcal cervicitis Approved [6]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-lactamase (blaB) DED0TBR A0A414M273_9BACE Substrate [4]
Beta-lactamase (blaB) DERGEVU C3WC84_FUSMR Substrate [4]
Beta-lactamase (blaB) DEQMISO F9Z530_ODOSD Substrate [4]
Beta-lactamase (blaB) DEHFJ4G Q8KT51_9BACT Substrate [4]
Beta-lactamase (blaB) DEHPJRC Q8KT60_9BACT Substrate [4]
Beta-lactamase (blaB) DE37FJH C6JIU1_FUSVA Substrate [5]
Beta-lactamase (blaB) DEF01WC A0A3S4HKA9_CHRVL Substrate [6]

References

1 Ticarcillin FDA Label
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050497.
3 Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus. Jpn J Antibiot. 1993 Jun;46(6):421-7.
4 Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6.
5 Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.
6 Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3.
7 Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80.
8 Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9.
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
11 Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32.
12 Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.
13 Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21.
14 Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.
15 In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enter... J Infect Dis. 2004 Dec 15;190(12):2162-6.
16 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.
17 Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9.