Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5EN79)

Drug Name

Levamisole Drug Info

Synonyms

Ketrax; LEVOMYSOL; Lepuron; Levamisol; Levamisolum; Levotetramisole; Tetramisol; Wormicid; Levamisole Base;Nilverm base; P00039; Vermisol 150; Dl-Tetramisol; Dl-Tetramisole; Ergamisol (TN); Ketrax (TN); L-Tetramisole; Levamisol [INN-Spanish]; Levamisole (INN); Levamisole [INN:BAN]; Levamisolum [INN-Latin]; TCMDC-125847; L(-)-Levamisole; L-2,3,5,6-Tetrahyro-6-phenylimidazo(2,1-b)thiazole; (-)-Tetramisole; (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole; (S)-(-)-Levamisole

Indication

Disease Entry	ICD 11	Status	REF
Parasitic infection	1D0Y-1G2Z	Approved	[1]
Colon cancer	2B90.Z	Withdrawn from market	[2]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 26879
ChEBI ID: CHEBI:6432
CAS Number: CAS 14769-73-4
TTD Drug ID: DM5EN79
INTEDE Drug ID: DR2400

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Alkaline phosphatase tissue-nonspecific (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Asfotase alfa	DMM4FXA	Genetic disease	8E02	Approved	[6]
DS-1211	DMY3T0L	Pseudoxanthoma elasticum	EC40	Phase 2	[7]
ALXN1850	DMSQPCT	Hypophosphatasia	5C64.3	Phase 1	[8]
ALXN1910	DMDXTAE	Discovery agent	N.A.	Phase 1	[8]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[14]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
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Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[27]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[28]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[39]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[45]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[46]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[48]
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Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[49]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[49]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[51]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Fructose	DM43AN2	Vomiting	MD90	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[70]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[71]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[72]
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Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[73]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[74]
Fructose	DM43AN2	Vomiting	MD90	Approved	[43]
Ketoprofen	DMRKXPT	Bursitis		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[47]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[76]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[77]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alkaline phosphatase tissue-nonspecific (ALPL)	TTMR5UV	PPBT_HUMAN	Inhibitor	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[4]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[4]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Gene/Protein Processing	[4]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Gene/Protein Processing	[4]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Gene/Protein Processing	[4]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Gene/Protein Processing	[4]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Gene/Protein Processing	[5]

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References

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