Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5F84A)

Drug Name

Pipecuronium Drug Info

Synonyms

Arduan; Pipecurium; Arduan (TN); Piperazinium, 4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl); [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate

Indication

Disease Entry	ICD 11	Status	REF
Spasm	MB47.3	Approved	[1]

Therapeutic Class

Analgesics

Cross-matching ID

PubChem CID: 50192
ChEBI ID: CHEBI:8230
CAS Number: CAS 68399-58-6
TTD Drug ID: DM5F84A

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[3]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[3]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[3]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[3]
Levallorphan	DMCOLUP	Narcotic depression	6A7Z	Approved	[2]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[3]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[2]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[4]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[5]
[125I]epibatidine	DMZWQH3	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Antagonist	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
3	Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
4	Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6.
5	Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 463).