Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5G9W0)

Drug Name

Taranabant Drug Info

Synonyms

Taranabant [USAN]; MK 0364; MK0364; MK-0364; MK-0634; Taranabant (INN/USAN); L]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide; N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropy; N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide; N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide; N-((1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Discontinued in Phase 3	[1]

Cross-matching ID

PubChem CID: 11226090
CAS Number: CAS 701977-09-5
TTD Drug ID: DM5G9W0

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cannabinoid receptor 1 (CB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[3]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[4]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[5]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[6]
Tebipenem	DMVSX6O	Urinary tract infection	GC08	Phase 3	[7]
Conatumumab	DM2UOSN	Colorectal cancer	2B91.Z	Phase 2	[8]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[9]
SR-147778	DMNAECP	Obesity	5B81	Phase 2	[10]
Nimacimab	DM21Z68	Diabetic nephropathy	GB61.Z	Phase 2	[11]
AEF0117	DMQ1GH4	Marijuana use disorder	6C41	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Antagonist	[2]

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References

1	Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
2	Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression. Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):133-44.
3	Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411.
4	Novel 1',1'-chain substituted hexahydrocannabinols: 9-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid r... J Med Chem. 2010 Oct 14;53(19):6996-7010.
5	Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. J Med Chem. 2008 Nov 13;51(21):6970-9.
6	Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
7	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
8	Clinical pipeline report, company report or official report of AstraZeneca (2009).
9	Company report (Gwpharm)
10	Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.Br J Clin Pharmacol.2013 Jul;76(1):65-77.
11	Clinical pipeline report, company report or official report of Bird Rock Bio.
12	Clinical pipeline report, company report or official report of Affimed Therapeutics.