Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5M4NT)

Drug Name

Ethacrynate Sodium Drug Info

Indication

Disease Entry	ICD 11	Status	REF
High blood pressure	BA00	Approved	[1]

Therapeutic Class

Cardiovascular Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Solute carrier family 12 member 1 (SLC12A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[3]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[2]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[4]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[5]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[6]
Torasemide	DMXKJ6C	Congestive heart failure	BD10	Approved	[7]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[8]
Trichlormethiazide	DMHAQCO	Hypertension	BA00-BA04	Approved	[9]
Hydroflumethiazide	DMVPUQI	Congestive heart failure	BD10	Approved	[8]
Methyclothiazide	DMN7SDE	Edema	MG29	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 12 member 1 (SLC12A1)	TTS087L	S12A1_HUMAN	Modulator	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Nongenomic effect of aldosterone on ion transport pathways of red blood cells. Cell Physiol Biochem. 2008;22(1-4):269-78.
4	Update of diuretics in the treatment of hypertension. Am J Ther. 2007 Mar-Apr;14(2):154-60.
5	Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem. 2009 Mar 27;284(13):8726-37.
6	Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. Am J Physiol. 1995 Apr;268(4 Pt 1):C1067-74.
7	Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9.
8	DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
9	Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model. J Hypertens. 2007 May;25(5):1065-72.