Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM68FZK)

Drug Name
Mercaptosuccinate Drug Info
Synonyms
Butanedioic acid, mercapto-; DL-Mercaptosuccinic acid; Malic acid, 2-thio-; Mercaptosuccinate; Mercaptosuccinic acid; Monomercaptosuccinic acid; NJRXVEJTAYWCQJ-UHFFFAOYSA-N; SUCCINIC ACID, MERCAPTO-; Thiomalate; Thiomalic acid; USAF EK-P-6297; USAF M-2; butanedioic acid, 2-mercapto-; (+/-)-Mercaptosuccinic acid; (1)-Mercaptosuccinic acid; .alpha.-Mercaptosuccinic acid; 2-Mercaptosuccinic acid; 2-Thiomalic acid; 2-sulfanylbutanedioic acid; 70-49-5; AI3-22956; BRN 1099858; C4H6O4S; EINECS 200-736-4; EINECS 211-423-7; NSC 7302
Cross-matching ID
PubChem CID
6268
ChEBI ID
CHEBI:38705
CAS Number
CAS 70-49-5
TTD Drug ID
DM68FZK
INTEDE Drug ID
DR2325

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Glutathione peroxidase 1 (GPX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [3]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [5]
Selenium DM25CGV N. A. N. A. Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [7]
Quercetin DM3NC4M Obesity 5B81 Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [11]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Mercaptosuccinate dioxygenase (efe) Main DME DEVNY51 EFE_PSESH Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Gene/Protein Processing [2]

References

1 Mercaptosuccinate dioxygenase, a cysteine dioxygenase homologue, from Variovorax paradoxus strain B4 is the key enzyme of mercaptosuccinate degradation. J Biol Chem. 2014 Oct 31;289(44):30800-9.
2 Resveratrol attenuates apoptosis of pulmonary microvascular endothelial cells induced by high shear stress and proinflammatory factors. Hum Cell. 2011 Sep;24(3):127-33.
3 Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
4 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
5 Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 2017 Sep 15;130(18):3009-3022. doi: 10.1242/jcs.198176. Epub 2017 Jul 25.
6 Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005 Jan 31;579(3):792-6. doi: 10.1016/j.febslet.2004.12.042.
7 Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism. PLoS One. 2014 Oct 20;9(10):e107299. doi: 10.1371/journal.pone.0107299. eCollection 2014.
8 A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells. Free Radic Res. 2008 Aug;42(8):746-53.
9 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
10 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
11 Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 Aug;27(8):1078-84.
12 Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats. Biol Trace Elem Res. 2007 Jun;116(3):329-48.