Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6XNJR)

Drug Name
SC-46553 Drug Info
Synonyms Ginsenoside 20-Glc-Rf; PubChem13034; SC-46553; ZINC238808898; ginsenoside-Rd; 705G938; CHEMBL525935; S597; Ginsenoside Rd
Cross-matching ID
PubChem CID
24721561
TTD Drug ID
DM6XNJR
INTEDE Drug ID
DR2742

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Beta-glucosidase (bglA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HY-N0040 DM349AM N. A. N. A. Preclinical [1]
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [1]
HY-N0040 DM349AM N. A. N. A. Preclinical [1]
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [1]
HY-N0040 DM349AM N. A. N. A. Preclinical [1]
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [2] , [1]
Ginsenoside Re DM46FVD N. A. N. A. Investigative [3]
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [3]
Ginsenoside Rg1 DMYE2SR N. A. N. A. Investigative [3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Beta-glucosidase (bglA) DEUO7V8 A0A509DD13_9STRE Substrate [1]
Beta-glucosidase (bglA) DE4LKZ9 A0A3D1ZWL4_9BIFI Substrate [1]
Beta-glucosidase (bglA) DEM6GYO A0A351PC96_9FIRM Substrate [2] , [1]
Beta-glucosidase (bglA) DE9N4OU C6WCL5_ACTMD Substrate [3]

References

1 Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.
2 Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 1998 Oct;50(10):1155-60.
3 Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59.