General Information of Drug (ID: DM6ZTOW)

Drug Name
Alpha-dihydroaldosterone Drug Info
Synonyms 5-Dihydroaldosterone; 5alpha-Dihydroaldosterone; 5Alpha-dihydroaldosterone; 6005-92-1; AC1MI1I2; 18,21-Dihydroxy-11,18-epoxypregnane-3,20-dione; DTXSID00975481
Cross-matching ID
PubChem CID
3036614
CAS Number
CAS 6005-92-1
TTD Drug ID
DM6ZTOW
INTEDE Drug ID
DR1957

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [2]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [6]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [8]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 2B7 (UGT2B7) Main DME DEB3CV1 UD2B7_HUMAN Substrate [1]

References

1 Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites. Endocrinology. 2003 Jun;144(6):2659-68.
2 Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy. Future Oncol. 2014 Jan;10(1):107-22.
3 Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 1;870(1):84-90.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5 Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600.
6 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
7 Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs. 2017 Apr;17(2):157-168.
8 Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9.
9 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
10 Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.