Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7GBDX)

Drug Name

N-Formylmethionine Drug Info

Synonyms

N-formyl-L-methionine; 4289-98-9; for-met-oh; N-FORMYLMETHIONINE; (S)-2-Formamido-4-(methylthio)butanoic acid; Formyl-L-methionine; formylmethionine; L-Methionine, N-formyl-; UNII-PS9357B4XH; N-Formyl-L -Methionine; PS9357B4XH; PYUSHNKNPOHWEZ-YFKPBYRVSA-N; N-Formyl methionine; L-Formylmethionine; L-N-Formylmethionine; N-Formyl(methyl)homocysteine #; Formyl-methionine; N-formyl-l-met; 2-formamido-4-methylsulfanylbutanoic acid; NSC 334322; Methionine, N-formyl-; AC1L97YW; SCHEMBL38595; CHEBI:16552; CTK1D5830; MolPort-006-116-105

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 439750
ChEBI ID: CHEBI:16552
CAS Number: CAS 4289-98-9
TTD Drug ID: DM7GBDX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Glutamate--cysteine ligase modifier (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cystamine	DMS5DHY	Discovery agent	N.A.	Investigative	[2]
Buthionine sulfoximine	DMJ46CB	Malaria	1F40-1F45	Investigative	[3]
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Drug(s) Targeting Antithrombin-III (ATIII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[4]
Heparin Calcium	DMEVXY6	Coagulation defect	3B10.0	Approved	[4]
Sulodexide	DMNUC42	Tinnitus	MC41	Approved	[5]
Heparin Sodium	DM9KHZL	Coagulation defect	3B10.0	Approved	[6]
Unfractionated heparin	DMCWM03	Thrombosis	DB61-GB90	Phase 3	[7]
Heparin low molecular weight	DMGFULM	Thrombosis	DB61-GB90	Phase 3	[8]
KW-3357	DMP3GI2	Coagulation defect	3B10.0	Phase 3	[9]
O-desulfated heparin	DMJL4A7	Chronic obstructive pulmonary disease	CA22	Phase 2	[10]
M118	DML0I2Z	Acute coronary syndrome	BA41	Phase 2	[11]
PMX-60056	DMWT73D	Coagulation defect	3B10.0	Phase 2	[12]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting NADH dehydrogenase (MT-ND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NADH	DM5NM6E	Parkinson disease	8A00.0	Approved	[13]
6-Thiophen-3-yl-imidazo[2,1-b]thiazole	DM90VJ6	Discovery agent	N.A.	Investigative	[14]
6-Thiophen-2-yl-imidazo[2,1-b]thiazole	DMC013U	Discovery agent	N.A.	Investigative	[14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Antithrombin-III (ATIII)	TT4QPUL	ANT3_HUMAN	Inhibitor	[1]
Glutamate--cysteine ligase modifier (GCLM)	TTNFESW	GSH0_HUMAN	Inhibitor	[1]
NADH dehydrogenase (MT-ND3)	TTTJF7V	NU3M_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	The gamma-glutamylcysteine synthetase of Onchocerca volvulus. Mol Biochem Parasitol. 2000 Dec;111(2):243-51.
3	Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Jan;18(1):1-20.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2632).
7	Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma. Thromb Res. 1982 Nov 15;28(4):487-97.
8	Effects of low molecular weight heparin on a severely antithrombin III-decreased disseminated intravascular coagulation model in rabbits. Thromb Res. 1995 Dec 1;80(5):391-8.
9	Company report (kyowa-kirin)
10	Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase. J Clin Invest. 1981 Jan;67(1):223-8.
11	Clinical pipeline report, company report or official report of Momentapharma.
12	Parenteral Anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Correction in: Chest. 2013 August; 144(2): 721.
13	Mechanism of cadmium-decreased glucuronidation in the rat. Biochem Pharmacol. 1992 Dec 1;44(11):2139-47.
14	Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase. J Med Chem. 1995 Mar 31;38(7):1090-7.