Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM83L5Y)

Drug Name

RIP Drug Info

Synonyms

beta-D-Ribopyranose; Ribose(Pyranose Form); 7296-60-8; UNII-49X539P7H4; CHEBI:27476; 49X539P7H4; (2R,3R,4R,5R)-oxane-2,3,4,5-tetrol; b-Ribopyranose; 115794-07-5; beta-D-Ribopyranose (9CI); 1ogd; 1drk; 2dri; 1drj; Ribopyranose, beta-D-; SCHEMBL625216; AC1L9B91; CHEMBL1159662; CTK4A9488; ZINC4097544; DB04286; 1577-EP2301533A1; 1577-EP2292630A1; 1577-EP2316459A1; 1577-EP2305808A1; 1577-EP2281563A1; C08353; 1577-EP2270015A1; 31308-EP2311817A1; 31308-EP2308858A1; 31308-EP2274983A1; 31308-EP2311816A1; 31308-EP2292088A1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 441481
ChEBI ID: CHEBI:27476
CAS Number: CAS 7296-60-8
TTD Drug ID: DM83L5Y

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[2]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[3]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[4]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[5]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[6]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[7]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[8]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[9]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[10]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[1]

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References

1	Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors. J Med Chem. 1985 Nov;28(11):1553-5.
2	Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
3	Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005 Sep;19(11):1474-81.
4	Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.
5	Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83.
6	Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
7	Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
8	Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.
9	Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7.
10	Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8.
11	Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient m... J Atheroscler Thromb. 2009 Jun;16(3):164-71.