Details of the Drug

General Information of Drug (ID: DM4L6EU)

Drug Name

Trandolapril

Synonyms

Gopten; Mavik; Odric; Odrik; Preran; Trandolaprilum; Udrik; Trandolaprilum [Latin]; RU 44570; RU44570; Mavik (TN); RU-44570; Trandolapril [INN:BAN]; Trandolapril (JAN/INN); (2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester; (2S,3aR,7aS)-1-(N-((1S)-1-((Ethyloxy)carbonyl)-3-phenylpropyl)-L-alanyl)octahydro-1H-indole-2-carboxylic Acid; (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylicacid; 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indol-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1], [2]

Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

430.5

Topological Polar Surface Area (xlogp)

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption: The absorption of drug is 40-60% [3]
BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [4]
Clearance: The drug present in the plasma can be removed from the body at the rate of 12.5 mL/min/kg [5]
Half-life: The concentration or amount of drug in body reduced by one-half in 6 - 10 hours [5]
Metabolism: The drug is metabolized via the liver [3]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.0618 micromolar/kg/day [6]
Unbound Fraction: The unbound fraction of drug in plasma is 0.17% [5]
Vd: The volume of distribution (Vd) of drug is 18 L [7]

Chemical Identifiers

Formula: C24H34N2O5
IUPAC Name: (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Canonical SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O
InChI: InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
InChIKey: VXFJYXUZANRPDJ-WTNASJBWSA-N

Cross-matching ID

PubChem CID: 5484727
ChEBI ID: CHEBI:9649
CAS Number: 87679-37-6
DrugBank ID: DB00519
TTD ID: D0M5OC
VARIDT ID: DR00240
INTEDE ID: DR2657
ACDINA ID: D00695

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[8]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[9]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[9]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Hypertension

ICD Disease Classification

BA00-BA04

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Angiotensin-converting enzyme (ACE)	DTT	SLC33A1	2.62E-01	-0.01	-0.06
Peptide transporter 1 (SLC15A1)	DTP	PEPT1	6.91E-01	8.30E-03	7.24E-02
Peptide transporter 2 (SLC15A2)	DTP	PEPT2	8.33E-02	-3.63E-02	-1.27E-01

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Trandolapril

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Eprosartan	DM07K2I	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Eprosartan.	Hypertension [BA00-BA04]	[33]
Aliskiren	DM1BV7W	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Aliskiren.	Hypertension [BA00-BA04]	[34]
Losartan	DM72JXH	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Losartan.	Hypertension [BA00-BA04]	[33]
Doxazosin	DM9PLRH	Moderate	Additive hypotensive effects by the combination of Trandolapril and Doxazosin.	Hypertension [BA00-BA04]	[35]
TAK-491	DMCF6SX	Major	Increased risk of hyperkalemia by the combination of Trandolapril and TAK-491.	Hypertension [BA00-BA04]	[33]
Indapamide	DMGN1PW	Moderate	Additive hypotensive effects by the combination of Trandolapril and Indapamide.	Hypertension [BA00-BA04]	[36]
Trichlormethiazide	DMHAQCO	Moderate	Additive hypotensive effects by the combination of Trandolapril and Trichlormethiazide.	Hypertension [BA00-BA04]	[36]
Telmisartan	DMS3GX2	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Telmisartan.	Hypertension [BA00-BA04]	[33]
Irbesartan	DMTP1DC	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Irbesartan.	Hypertension [BA00-BA04]	[37]
Hydrochlorothiazide	DMUSZHD	Moderate	Additive hypotensive effects by the combination of Trandolapril and Hydrochlorothiazide.	Hypertension [BA00-BA04]	[36]
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⏷ Show the Full List of 10 DDI Information of This Drug

Coadministration of a Drug Treating the Disease Different from Trandolapril (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[38]
Sodium bicarbonate	DMMU6BJ	Minor	Decreased absorption of Trandolapril due to altered gastric pH caused by Sodium bicarbonate.	Acidosis [5C73]	[39]
Repaglinide	DM5SXUV	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Repaglinide.	Acute diabete complication [5A2Y]	[40]
Glibenclamide	DM8JXPZ	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Glibenclamide.	Acute diabete complication [5A2Y]	[40]
Tolazamide	DMIHRNA	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Tolazamide.	Acute diabete complication [5A2Y]	[40]
Insulin-glulisine	DMQI0FU	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Insulin-glulisine.	Acute diabete complication [5A2Y]	[40]
Insulin-aspart	DMX7V28	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Insulin-aspart.	Acute diabete complication [5A2Y]	[41]
Glipizide	DMZA5PQ	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Glipizide.	Acute diabete complication [5A2Y]	[40]
Isosorbide dinitrate	DMBI4JG	Moderate	Additive hypotensive effects by the combination of Trandolapril and Isosorbide dinitrate.	Anal fissure/fistula [DB50]	[42]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[43]
Linezolid	DMGFPU2	Moderate	Additive hypotensive effects by the combination of Trandolapril and Linezolid.	Bacterial infection [1A00-1C4Z]	[44]
Cariprazine	DMJYDVK	Moderate	Additive hypotensive effects by the combination of Trandolapril and Cariprazine.	Bipolar disorder [6A60]	[45]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Trandolapril and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[46]
Mannitol	DMSCDY9	Moderate	Additive hypotensive effects by the combination of Trandolapril and Mannitol.	Bronchiectasis [CA24]	[36]
Olopatadine	DMKMWQG	Moderate	Additive CNS depression effects by the combination of Trandolapril and Olopatadine.	Conjunctiva disorder [9A60]	[47]
Drospirenone	DM1A9W3	Moderate	Increased risk of hyperkalemia by the combination of Trandolapril and Drospirenone.	Contraceptive management [QA21]	[48]
Ardeparin	DMYRX8B	Moderate	Increased risk of hyperkalemia by the combination of Trandolapril and Ardeparin.	Coronary thrombosis [BA43]	[33]
Selegiline	DM6034S	Moderate	Additive hypotensive effects by the combination of Trandolapril and Selegiline.	Depression [6A70-6A7Z]	[44]
Isocarboxazid	DMAF1NB	Moderate	Additive hypotensive effects by the combination of Trandolapril and Isocarboxazid.	Depression [6A70-6A7Z]	[44]
OPC-34712	DMHG57U	Moderate	Additive hypotensive effects by the combination of Trandolapril and OPC-34712.	Depression [6A70-6A7Z]	[45]
Phenelzine	DMHIDUE	Moderate	Additive hypotensive effects by the combination of Trandolapril and Phenelzine.	Depression [6A70-6A7Z]	[44]
Nitroglycerin	DMQ2491	Moderate	Additive hypotensive effects by the combination of Trandolapril and Nitroglycerin.	Diabetic foot ulcer [BD54]	[42]
SODIUM CITRATE	DMHPD2Y	Minor	Decreased absorption of Trandolapril due to altered gastric pH caused by SODIUM CITRATE.	Discovery agent [N.A.]	[39]
Ethacrynic acid	DM60QMR	Moderate	Additive hypotensive effects by the combination of Trandolapril and Ethacrynic acid.	Essential hypertension [BA00]	[49]
Phenoxybenzamine	DM8KSQH	Moderate	Additive hypotensive effects by the combination of Trandolapril and Phenoxybenzamine.	Essential hypertension [BA00]	[35]
Benzthiazide	DMQWZ0H	Moderate	Additive hypotensive effects by the combination of Trandolapril and Benzthiazide.	Essential hypertension [BA00]	[36]
Acetazolamide	DM1AF5U	Moderate	Additive hypotensive effects by the combination of Trandolapril and Acetazolamide.	Glaucoma [9C61]	[36]
Methazolamide	DM7J2TA	Moderate	Additive hypotensive effects by the combination of Trandolapril and Methazolamide.	Glaucoma [9C61]	[36]
Dichlorphenamide	DMH7IDQ	Moderate	Additive hypotensive effects by the combination of Trandolapril and Dichlorphenamide.	Glaucoma [9C61]	[49]
Eplerenone	DMF0NQR	Moderate	Increased risk of hyperkalemia by the combination of Trandolapril and Eplerenone.	Heart failure [BD10-BD1Z]	[50]
Chlorothiazide	DMLHESP	Moderate	Additive hypotensive effects by the combination of Trandolapril and Chlorothiazide.	Heart failure [BD10-BD1Z]	[36]
Furosemide	DMMQ8ZG	Moderate	Additive hypotensive effects by the combination of Trandolapril and Furosemide.	Heart failure [BD10-BD1Z]	[36]
Amiloride	DMRTSGP	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Amiloride.	Heart failure [BD10-BD1Z]	[51]
Bumetanide	DMRV7H0	Moderate	Additive hypotensive effects by the combination of Trandolapril and Bumetanide.	Heart failure [BD10-BD1Z]	[36]
Procarbazine	DMIK367	Moderate	Additive hypotensive effects by the combination of Trandolapril and Procarbazine.	Hodgkin lymphoma [2B30]	[44]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[52]
Efavirenz	DMC0GSJ	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Efavirenz.	Human immunodeficiency virus disease [1C60-1C62]	[53]
Didanosine	DMI2QPE	Minor	Decreased absorption of Trandolapril due to altered gastric pH caused by Didanosine.	Human immunodeficiency virus disease [1C60-1C62]	[39]
Isosorbide mononitrate	DMYLMU0	Moderate	Additive hypotensive effects by the combination of Trandolapril and Isosorbide mononitrate.	Hydrocephalus [8D64]	[42]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Trandolapril and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[54]
Teriflunomide	DMQ2FKJ	Major	Increased risk of hepatotoxicity by the combination of Trandolapril and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[55]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Trandolapril and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[56]
Potassium chloride	DMMTAJC	Major	Increased risk of hyperkalemia by the combination of Trandolapril and Potassium chloride.	Hypo-kalaemia [5C77]	[57]
Tolvaptan	DMIWFRL	Moderate	Increased risk of hyperkalemia by the combination of Trandolapril and Tolvaptan.	Hypo-osmolality/hyponatraemia [5C72]	[58]
Propiomazine	DMKY8V1	Moderate	Additive hypotensive effects by the combination of Trandolapril and Propiomazine.	Insomnia [7A00-7A0Z]	[45]
ITI-007	DMUQ1DO	Moderate	Additive hypotensive effects by the combination of Trandolapril and ITI-007.	Insomnia [7A00-7A0Z]	[45]
Methotrexate	DM2TEOL	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Methotrexate.	Leukaemia [2A60-2B33]	[59]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[60]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Idelalisib.	Mature B-cell leukaemia [2A82]	[61]
Lanthanum carbonate	DMMJQSH	Moderate	Decreased absorption of Trandolapril due to formation of complexes caused by Lanthanum carbonate.	Mineral absorption/transport disorder [5C64]	[55]
Ozanimod	DMT6AM2	Moderate	Additive hypotensive effects by the combination of Trandolapril and Ozanimod.	Multiple sclerosis [8A40]	[44]
Promethazine	DM6I5GR	Moderate	Additive hypotensive effects by the combination of Trandolapril and Promethazine.	Nausea/vomiting [MD90]	[45]
Metolazone	DMB39LO	Moderate	Additive hypotensive effects by the combination of Trandolapril and Metolazone.	Oedema [MG29]	[36]
Polythiazide	DMCH80F	Moderate	Additive hypotensive effects by the combination of Trandolapril and Polythiazide.	Oedema [MG29]	[36]
Safinamide	DM0YWJC	Moderate	Additive hypotensive effects by the combination of Trandolapril and Safinamide.	Parkinsonism [8A00]	[44]
Rasagiline	DM3WKQ4	Moderate	Additive hypotensive effects by the combination of Trandolapril and Rasagiline.	Parkinsonism [8A00]	[44]
Terazosin	DM3JCVS	Moderate	Additive hypotensive effects by the combination of Trandolapril and Terazosin.	Prostate hyperplasia [GA90]	[35]
Silodosin	DMJSBT6	Moderate	Additive hypotensive effects by the combination of Trandolapril and Silodosin.	Prostate hyperplasia [GA90]	[35]
Levomepromazine	DMIKFEL	Moderate	Additive hypotensive effects by the combination of Trandolapril and Levomepromazine.	Psychotic disorder [6A20-6A25]	[45]
Fluphenazine	DMIT8LX	Moderate	Additive hypotensive effects by the combination of Trandolapril and Fluphenazine.	Psychotic disorder [6A20-6A25]	[45]
Leflunomide	DMR8ONJ	Major	Increased risk of hepatotoxicity by the combination of Trandolapril and Leflunomide.	Rheumatoid arthritis [FA20]	[55]
Quetiapine	DM1N62C	Moderate	Additive hypotensive effects by the combination of Trandolapril and Quetiapine.	Schizophrenia [6A20]	[45]
Mesoridazine	DM2ZGAN	Moderate	Additive hypotensive effects by the combination of Trandolapril and Mesoridazine.	Schizophrenia [6A20]	[45]
Thioridazine	DM35M8J	Moderate	Additive hypotensive effects by the combination of Trandolapril and Thioridazine.	Schizophrenia [6A20]	[45]
Aripiprazole	DM3NUMH	Moderate	Additive hypotensive effects by the combination of Trandolapril and Aripiprazole.	Schizophrenia [6A20]	[45]
Iloperidone	DM6AUFY	Moderate	Additive hypotensive effects by the combination of Trandolapril and Iloperidone.	Schizophrenia [6A20]	[45]
Paliperidone	DM7NPJS	Moderate	Additive hypotensive effects by the combination of Trandolapril and Paliperidone.	Schizophrenia [6A20]	[45]
Molindone	DMAH70G	Moderate	Additive hypotensive effects by the combination of Trandolapril and Molindone.	Schizophrenia [6A20]	[45]
Thiothixene	DMDINC4	Moderate	Additive hypotensive effects by the combination of Trandolapril and Thiothixene.	Schizophrenia [6A20]	[45]
Trifluoperazine	DMKBYWI	Moderate	Additive hypotensive effects by the combination of Trandolapril and Trifluoperazine.	Schizophrenia [6A20]	[45]
Risperidone	DMN6DXL	Moderate	Additive hypotensive effects by the combination of Trandolapril and Risperidone.	Schizophrenia [6A20]	[45]
Amisulpride	DMSJVAM	Moderate	Additive hypotensive effects by the combination of Trandolapril and Amisulpride.	Schizophrenia [6A20]	[45]
Asenapine	DMSQZE2	Moderate	Additive hypotensive effects by the combination of Trandolapril and Asenapine.	Schizophrenia [6A20]	[45]
Trabectedin	DMG3Y89	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Trabectedin.	Solid tumour/cancer [2A00-2F9Z]	[59]
Naltrexone	DMUL45H	Moderate	Increased risk of hepatotoxicity by the combination of Trandolapril and Naltrexone.	Substance abuse [6C40]	[62]
Tacrolimus	DMZ7XNQ	Moderate	Increased risk of hyperkalemia by the combination of Trandolapril and Tacrolimus.	Transplant rejection [NE84]	[63]
Tolbutamide	DM02AWV	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Tolbutamide.	Type 2 diabetes mellitus [5A11]	[40]
Chlorpropamide	DMPHZQE	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Chlorpropamide.	Type 2 diabetes mellitus [5A11]	[40]
Insulin-detemir	DMOA4VW	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Insulin-detemir.	Type-1/2 diabete [5A10-5A11]	[40]
Insulin degludec	DMPL395	Moderate	Increased risk of hypoglycemia by the combination of Trandolapril and Insulin degludec.	Type-1/2 diabete [5A10-5A11]	[40]
Trimeprazine	DMEMV9D	Moderate	Additive hypotensive effects by the combination of Trandolapril and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[64]
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⏷ Show the Full List of 81 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Allura red AC dye	E00338	33258	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Sodium stearyl fumarate	E00545	23665634	lubricant
Sunset yellow FCF	E00255	17730	Colorant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Carmellose sodium	E00625	Not Available	Disintegrant
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Hypromellose	E00634	Not Available	Coating agent
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
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⏷ Show the Full List of 12 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Trandolapril 1 mg tablet	1 mg	Oral Tablet	Oral
Trandolapril 2 mg tablet	2 mg	Oral Tablet	Oral
Trandolapril 4 mg tablet	4 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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