Details of the Drug

General Information of Drug (ID: DMOPZDT)

Drug Name

Perindopril

Synonyms

ACEON; Coverex; Coversum; Coversyl; Prestarium; Coverene Cor; Cpd with unspecified MF; Aceon (TN); Acertil (TN); Armix (TN); Coverene (TN); Coverex (TN); Coversum (TN); DW-7950; Prestarium (TN); Prexanil (TN); Prexum (TN); Procaptan (TN); S-9490; SED-9490; McN-A-2833; Perindopril (USAN/INN); Ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate; (2S)-2-[(1S)-1-Carbethoxybutylamino]-1-oxopropyl-(2S,3aS,7aS)-perhydroindole-2-carboxylic acid; (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1], [2]

Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

368.5

Topological Polar Surface Area (xlogp)

0.9

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Elimination: 8% of drug is excreted from urine in the unchanged form [3]
Half-life: The concentration or amount of drug in body reduced by one-half in 1.2 hours [4]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.60385 micromolar/kg/day [5]

Chemical Identifiers

Formula: C19H32N2O5
IUPAC Name: (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Canonical SMILES: CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O
InChI: InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
InChIKey: IPVQLZZIHOAWMC-QXKUPLGCSA-N

Cross-matching ID

PubChem CID: 107807
ChEBI ID: CHEBI:8024
CAS Number: 82834-16-0
DrugBank ID: DB00790
TTD ID: D03KYG
VARIDT ID: DR00058
ACDINA ID: D00520

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[6]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[7]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[7]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Hypertension

ICD Disease Classification

BA00-BA04

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Angiotensin-converting enzyme (ACE)	DTT	SLC33A1	2.62E-01	-0.01	-0.06
Peptide transporter 1 (SLC15A1)	DTP	PEPT1	6.91E-01	8.30E-03	7.24E-02
Peptide transporter 2 (SLC15A2)	DTP	PEPT2	8.33E-02	-3.63E-02	-1.27E-01

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Perindopril

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Eprosartan	DM07K2I	Major	Increased risk of hyperkalemia by the combination of Perindopril and Eprosartan.	Hypertension [BA00-BA04]	[31]
Aliskiren	DM1BV7W	Major	Increased risk of hyperkalemia by the combination of Perindopril and Aliskiren.	Hypertension [BA00-BA04]	[32]
TAK-491	DMCF6SX	Major	Increased risk of hyperkalemia by the combination of Perindopril and TAK-491.	Hypertension [BA00-BA04]	[31]
Trichlormethiazide	DMHAQCO	Moderate	Additive hypotensive effects by the combination of Perindopril and Trichlormethiazide.	Hypertension [BA00-BA04]	[33]
Telmisartan	DMS3GX2	Major	Increased risk of hyperkalemia by the combination of Perindopril and Telmisartan.	Hypertension [BA00-BA04]	[31]
Irbesartan	DMTP1DC	Major	Increased risk of hyperkalemia by the combination of Perindopril and Irbesartan.	Hypertension [BA00-BA04]	[34]
Hydrochlorothiazide	DMUSZHD	Moderate	Additive hypotensive effects by the combination of Perindopril and Hydrochlorothiazide.	Hypertension [BA00-BA04]	[33]
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⏷ Show the Full List of 7 DDI Information of This Drug

Coadministration of a Drug Treating the Disease Different from Perindopril (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[35]
Sodium bicarbonate	DMMU6BJ	Minor	Decreased absorption of Perindopril due to altered gastric pH caused by Sodium bicarbonate.	Acidosis [5C73]	[36]
Repaglinide	DM5SXUV	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Repaglinide.	Acute diabete complication [5A2Y]	[37]
Glibenclamide	DM8JXPZ	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Glibenclamide.	Acute diabete complication [5A2Y]	[37]
Tolazamide	DMIHRNA	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Tolazamide.	Acute diabete complication [5A2Y]	[37]
Insulin-glulisine	DMQI0FU	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Insulin-glulisine.	Acute diabete complication [5A2Y]	[37]
Insulin-aspart	DMX7V28	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Insulin-aspart.	Acute diabete complication [5A2Y]	[38]
Glipizide	DMZA5PQ	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Glipizide.	Acute diabete complication [5A2Y]	[37]
Isosorbide dinitrate	DMBI4JG	Moderate	Additive hypotensive effects by the combination of Perindopril and Isosorbide dinitrate.	Anal fissure/fistula [DB50]	[39]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[40]
Gentamicin	DMKINJO	Minor	Increased risk of nephrotoxicity by the combination of Perindopril and Gentamicin.	Bacterial infection [1A00-1C4Z]	[41]
Cariprazine	DMJYDVK	Moderate	Additive hypotensive effects by the combination of Perindopril and Cariprazine.	Bipolar disorder [6A60]	[42]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Perindopril and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[43]
Drospirenone	DM1A9W3	Moderate	Increased risk of hyperkalemia by the combination of Perindopril and Drospirenone.	Contraceptive management [QA21]	[44]
Ardeparin	DMYRX8B	Moderate	Increased risk of hyperkalemia by the combination of Perindopril and Ardeparin.	Coronary thrombosis [BA43]	[31]
Selegiline	DM6034S	Moderate	Additive hypotensive effects by the combination of Perindopril and Selegiline.	Depression [6A70-6A7Z]	[45]
OPC-34712	DMHG57U	Moderate	Additive hypotensive effects by the combination of Perindopril and OPC-34712.	Depression [6A70-6A7Z]	[42]
SODIUM CITRATE	DMHPD2Y	Minor	Decreased absorption of Perindopril due to altered gastric pH caused by SODIUM CITRATE.	Discovery agent [N.A.]	[36]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Cannabidiol.	Epileptic encephalopathy [8A62]	[46]
Ethacrynic acid	DM60QMR	Moderate	Additive hypotensive effects by the combination of Perindopril and Ethacrynic acid.	Essential hypertension [BA00]	[47]
Phenoxybenzamine	DM8KSQH	Moderate	Additive hypotensive effects by the combination of Perindopril and Phenoxybenzamine.	Essential hypertension [BA00]	[48]
Acetazolamide	DM1AF5U	Moderate	Additive hypotensive effects by the combination of Perindopril and Acetazolamide.	Glaucoma [9C61]	[33]
Dichlorphenamide	DMH7IDQ	Moderate	Additive hypotensive effects by the combination of Perindopril and Dichlorphenamide.	Glaucoma [9C61]	[47]
Chlorothiazide	DMLHESP	Moderate	Additive hypotensive effects by the combination of Perindopril and Chlorothiazide.	Heart failure [BD10-BD1Z]	[33]
Bumetanide	DMRV7H0	Moderate	Additive hypotensive effects by the combination of Perindopril and Bumetanide.	Heart failure [BD10-BD1Z]	[33]
Procarbazine	DMIK367	Moderate	Additive hypotensive effects by the combination of Perindopril and Procarbazine.	Hodgkin lymphoma [2B30]	[45]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[49]
Didanosine	DMI2QPE	Minor	Decreased absorption of Perindopril due to altered gastric pH caused by Didanosine.	Human immunodeficiency virus disease [1C60-1C62]	[36]
Isosorbide mononitrate	DMYLMU0	Moderate	Additive hypotensive effects by the combination of Perindopril and Isosorbide mononitrate.	Hydrocephalus [8D64]	[39]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Perindopril and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[50]
Teriflunomide	DMQ2FKJ	Major	Increased risk of hepatotoxicity by the combination of Perindopril and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[51]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Perindopril and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[52]
Tolvaptan	DMIWFRL	Moderate	Increased risk of hyperkalemia by the combination of Perindopril and Tolvaptan.	Hypo-osmolality/hyponatraemia [5C72]	[53]
ITI-007	DMUQ1DO	Moderate	Additive hypotensive effects by the combination of Perindopril and ITI-007.	Insomnia [7A00-7A0Z]	[42]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[54]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Idelalisib.	Mature B-cell leukaemia [2A82]	[55]
Lanthanum carbonate	DMMJQSH	Moderate	Decreased absorption of Perindopril due to formation of complexes caused by Lanthanum carbonate.	Mineral absorption/transport disorder [5C64]	[51]
Ozanimod	DMT6AM2	Moderate	Additive hypotensive effects by the combination of Perindopril and Ozanimod.	Multiple sclerosis [8A40]	[45]
Promethazine	DM6I5GR	Moderate	Additive hypotensive effects by the combination of Perindopril and Promethazine.	Nausea/vomiting [MD90]	[42]
Polythiazide	DMCH80F	Moderate	Additive hypotensive effects by the combination of Perindopril and Polythiazide.	Oedema [MG29]	[33]
Rasagiline	DM3WKQ4	Moderate	Additive hypotensive effects by the combination of Perindopril and Rasagiline.	Parkinsonism [8A00]	[45]
Terazosin	DM3JCVS	Moderate	Additive hypotensive effects by the combination of Perindopril and Terazosin.	Prostate hyperplasia [GA90]	[48]
Silodosin	DMJSBT6	Moderate	Additive hypotensive effects by the combination of Perindopril and Silodosin.	Prostate hyperplasia [GA90]	[48]
Levomepromazine	DMIKFEL	Moderate	Additive hypotensive effects by the combination of Perindopril and Levomepromazine.	Psychotic disorder [6A20-6A25]	[42]
Leflunomide	DMR8ONJ	Major	Increased risk of hepatotoxicity by the combination of Perindopril and Leflunomide.	Rheumatoid arthritis [FA20]	[51]
Quetiapine	DM1N62C	Moderate	Additive hypotensive effects by the combination of Perindopril and Quetiapine.	Schizophrenia [6A20]	[42]
Mesoridazine	DM2ZGAN	Moderate	Additive hypotensive effects by the combination of Perindopril and Mesoridazine.	Schizophrenia [6A20]	[42]
Aripiprazole	DM3NUMH	Moderate	Additive hypotensive effects by the combination of Perindopril and Aripiprazole.	Schizophrenia [6A20]	[42]
Iloperidone	DM6AUFY	Moderate	Additive hypotensive effects by the combination of Perindopril and Iloperidone.	Schizophrenia [6A20]	[42]
Paliperidone	DM7NPJS	Moderate	Additive hypotensive effects by the combination of Perindopril and Paliperidone.	Schizophrenia [6A20]	[42]
Perphenazine	DMA4MRX	Moderate	Additive hypotensive effects by the combination of Perindopril and Perphenazine.	Schizophrenia [6A20]	[42]
Molindone	DMAH70G	Moderate	Additive hypotensive effects by the combination of Perindopril and Molindone.	Schizophrenia [6A20]	[42]
Thiothixene	DMDINC4	Moderate	Additive hypotensive effects by the combination of Perindopril and Thiothixene.	Schizophrenia [6A20]	[42]
Trifluoperazine	DMKBYWI	Moderate	Additive hypotensive effects by the combination of Perindopril and Trifluoperazine.	Schizophrenia [6A20]	[42]
Amisulpride	DMSJVAM	Moderate	Additive hypotensive effects by the combination of Perindopril and Amisulpride.	Schizophrenia [6A20]	[42]
Asenapine	DMSQZE2	Moderate	Additive hypotensive effects by the combination of Perindopril and Asenapine.	Schizophrenia [6A20]	[42]
Trabectedin	DMG3Y89	Moderate	Increased risk of hepatotoxicity by the combination of Perindopril and Trabectedin.	Solid tumour/cancer [2A00-2F9Z]	[46]
Tacrolimus	DMZ7XNQ	Moderate	Increased risk of hyperkalemia by the combination of Perindopril and Tacrolimus.	Transplant rejection [NE84]	[56]
Tolbutamide	DM02AWV	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Tolbutamide.	Type 2 diabetes mellitus [5A11]	[37]
Insulin-detemir	DMOA4VW	Moderate	Increased risk of hypoglycemia by the combination of Perindopril and Insulin-detemir.	Type-1/2 diabete [5A10-5A11]	[37]
Methdilazine	DMAUHQX	Moderate	Additive hypotensive effects by the combination of Perindopril and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[42]
Trimeprazine	DMEMV9D	Moderate	Additive hypotensive effects by the combination of Perindopril and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[57]
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⏷ Show the Full List of 62 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Eisenoxyd	E00585	56841934	Colorant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
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Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Perindopril 4 mg tablet	4 mg	Oral Tablet	Oral
Perindopril 8 mg tablet	8 mg	Oral Tablet	Oral
Perindopril 2 mg tablet	2 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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