Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8U70E)

Drug Name
N-Butyl-N'-(4-methyl-benzoyl)-guanidine Drug Info
Synonyms CHEMBL432963; SCHEMBL4629393; BDBM50107019; 1-Butyl-2-(4-methylbenzoyl)guanidine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10955473
TTD Drug ID
DM8U70E

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [2]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [3]
Fosphenytoin DMOX3LB Epilepsy 8A60-8A68 Approved [2]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [3]
LOMERIZINE DME0TC8 Migraine 8A80 Approved [4]
Tetrodotoxin DMWMPRG Bacterial infection 1A00-1C4Z Approved [5]
Dyclonine DMU6OFP Pain MG30-MG3Z Approved [6]
Moricizine DMOMBJW Arrhythmia BC9Z Approved [7]
Ethotoin DMXWOCP Complex partial seizure 8A68.0 Approved [8]
Prilocaine DMI7DZ2 Pain MG30-MG3Z Approved [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.5 (SCN5A) TTZOVE0 SCN5A_HUMAN Inhibitor [1]

References

1 Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3151-5.
2 Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
3 Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9.
4 Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
5 Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81.
6 Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.
7 From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.