DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Remdesivir |
DMBFZ6L
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Remdesivir. |
1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]
|
[14] |
Emapalumab |
DMZG5WL
|
Moderate |
Altered metabolism of Mephenytoin due to Emapalumab alters the formation of CYP450 enzymes. |
Adaptive immunity immunodeficiency [4A01]
|
[18] |
Mitotane |
DMU1GX0
|
Minor |
Increased metabolism of Mephenytoin caused by Mitotane mediated induction of CYP450 enzyme. |
Adrenal cancer [2D11]
|
[19] |
Siltuximab |
DMGEATB
|
Moderate |
Altered metabolism of Mephenytoin due to Siltuximab alters the formation of CYP450 enzymes. |
Anemia [3A00-3A9Z]
|
[18] |
Bepridil |
DM0RKS4
|
Moderate |
Increased metabolism of Mephenytoin caused by Bepridil mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[20] |
Nifedipine |
DMSVOZT
|
Moderate |
Increased metabolism of Mephenytoin caused by Nifedipine mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[20] |
Bedaquiline |
DM3906J
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Bedaquiline. |
Antimicrobial drug resistance [MG50-MG52]
|
[21] |
Clorazepate |
DMC3JST
|
Moderate |
Increased metabolism of Mephenytoin caused by Clorazepate mediated induction of CYP450 enzyme. |
Anxiety disorder [6B00-6B0Z]
|
[22] |
Voriconazole |
DMAOL2S
|
Moderate |
Decreased metabolism of Mephenytoin caused by Voriconazole mediated inhibition of CYP450 enzyme. |
Aspergillosis [1F20]
|
[14] |
Aminophylline |
DML2NIB
|
Moderate |
Increased metabolism of Mephenytoin caused by Aminophylline mediated induction of CYP450 enzyme. |
Asthma [CA23]
|
[23] |
Clarithromycin |
DM4M1SG
|
Moderate |
Increased metabolism of Mephenytoin caused by Clarithromycin mediated induction of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[24] |
Troleandomycin |
DMUZNIG
|
Moderate |
Increased metabolism of Mephenytoin caused by Troleandomycin mediated induction of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[14] |
Pexidartinib |
DMS2J0Z
|
Major |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Pexidartinib. |
Bone/articular cartilage neoplasm [2F7B]
|
[25] |
Alpelisib |
DMEXMYK
|
Moderate |
Increased metabolism of Mephenytoin caused by Alpelisib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[26] |
Levomilnacipran |
DMV26S8
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Levomilnacipran. |
Chronic pain [MG30]
|
[27] |
Anisindione |
DM2C48U
|
Moderate |
Increased metabolism of Mephenytoin caused by Anisindione mediated induction of CYP450 enzyme. |
Coagulation defect [3B10]
|
[28] |
Tubocurarine |
DMBZIVP
|
Moderate |
Increased metabolism of Mephenytoin caused by Tubocurarine mediated induction of CYP450 enzyme. |
Corneal disease [9A76-9A78]
|
[14] |
Oxtriphylline |
DMLHSE3
|
Moderate |
Increased metabolism of Mephenytoin caused by Oxtriphylline mediated induction of CYP450 enzyme. |
Cough [MD12]
|
[29] |
Mycophenolic acid |
DMRBMAU
|
Minor |
Increased plasma concentration of Mephenytoin and Mycophenolic acid due to competitive binding of plasma proteins. |
Crohn disease [DD70]
|
[30] |
Mifepristone |
DMGZQEF
|
Moderate |
Decreased metabolism of Mephenytoin caused by Mifepristone mediated inhibition of CYP450 enzyme. |
Cushing syndrome [5A70]
|
[31] |
Osilodrostat |
DMIJC9X
|
Moderate |
Decreased metabolism of Mephenytoin caused by Osilodrostat mediated inhibition of CYP450 enzyme. |
Cushing syndrome [5A70]
|
[32] |
Ethanol |
DMDRQZU
|
Moderate |
Additive CNS depression effects by the combination of Mephenytoin and Ethanol. |
Cystitis [GC00]
|
[14] |
MK-8228 |
DMOB58Q
|
Moderate |
Increased metabolism of Mephenytoin caused by MK-8228 mediated induction of CYP450 enzyme. |
Cytomegaloviral disease [1D82]
|
[33] |
Vilazodone |
DM4LECQ
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Vilazodone. |
Depression [6A70-6A7Z]
|
[27] |
Paroxetine |
DM5PVQE
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Paroxetine. |
Depression [6A70-6A7Z]
|
[27] |
Vortioxetine |
DM6F1PU
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Vortioxetine. |
Depression [6A70-6A7Z]
|
[27] |
Milnacipran |
DMBFE74
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Milnacipran. |
Depression [6A70-6A7Z]
|
[27] |
Desvenlafaxine |
DMHD4PE
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Desvenlafaxine. |
Depression [6A70-6A7Z]
|
[27] |
Esketamine |
DMVU687
|
Moderate |
Additive CNS depression effects by the combination of Mephenytoin and Esketamine. |
Depression [6A70-6A7Z]
|
[14] |
Cannabidiol |
DM0659E
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Cannabidiol. |
Epileptic encephalopathy [8A62]
|
[34] |
Nicardipine |
DMCDYW7
|
Moderate |
Increased metabolism of Mephenytoin caused by Nicardipine mediated induction of CYP450 enzyme. |
Essential hypertension [BA00]
|
[20] |
Itraconazole |
DMCR1MV
|
Moderate |
Increased metabolism of Mephenytoin caused by Itraconazole mediated induction of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[14] |
Miconazole |
DMPMYE8
|
Moderate |
Decreased metabolism of Mephenytoin caused by Miconazole mediated inhibition of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[35] |
Ketoconazole |
DMPZI3Q
|
Moderate |
Increased metabolism of Mephenytoin caused by Ketoconazole mediated induction of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[14] |
Isoniazid |
DM5JVS3
|
Moderate |
Decreased metabolism of Mephenytoin caused by Isoniazid mediated inhibition of CYP450 enzyme. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[14] |
Efavirenz |
DMC0GSJ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Efavirenz. |
Human immunodeficiency virus disease [1C60-1C62]
|
[36] |
Etravirine |
DMGV8QU
|
Moderate |
Decreased metabolism of Mephenytoin caused by Etravirine mediated inhibition of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[37] |
Fenofibrate |
DMFKXDY
|
Moderate |
Decreased metabolism of Mephenytoin caused by Fenofibrate mediated inhibition of CYP450 enzyme. |
Hyper-lipoproteinaemia [5C80]
|
[14] |
Mipomersen |
DMGSRN1
|
Major |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Mipomersen. |
Hyper-lipoproteinaemia [5C80]
|
[38] |
Clofibrate |
DMPC1J7
|
Minor |
Increased plasma concentration of Mephenytoin and Clofibrate due to competitive binding of plasma proteins. |
Hyper-lipoproteinaemia [5C80]
|
[14] |
Teriflunomide |
DMQ2FKJ
|
Major |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Teriflunomide. |
Hyper-lipoproteinaemia [5C80]
|
[39] |
BMS-201038 |
DMQTAGO
|
Major |
Increased risk of hepatotoxicity by the combination of Mephenytoin and BMS-201038. |
Hyper-lipoproteinaemia [5C80]
|
[40] |
Levamlodipine |
DM92S6N
|
Moderate |
Increased metabolism of Mephenytoin caused by Levamlodipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[20] |
Verapamil |
DMA7PEW
|
Moderate |
Increased metabolism of Mephenytoin caused by Verapamil mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[41] |
Felodipine |
DMOSW35
|
Moderate |
Increased metabolism of Mephenytoin caused by Felodipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[42] |
Fludrocortisone |
DMUDIR8
|
Moderate |
Increased metabolism of Mephenytoin caused by Fludrocortisone mediated induction of CYP450 enzyme. |
Hypo-osmolality/hyponatraemia [5C72]
|
[43] |
Flurazepam |
DMAL4G0
|
Moderate |
Increased metabolism of Mephenytoin caused by Flurazepam mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[13] |
Triazolam |
DMETYK5
|
Moderate |
Increased metabolism of Mephenytoin caused by Triazolam mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[13] |
Quazepam |
DMY4D87
|
Moderate |
Increased metabolism of Mephenytoin caused by Quazepam mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[13] |
Estazolam |
DMZGXUM
|
Moderate |
Increased metabolism of Mephenytoin caused by Estazolam mediated induction of CYP450 enzyme. |
Insomnia [7A00-7A0Z]
|
[13] |
Remimazolam |
DMLVSYX
|
Moderate |
Increased metabolism of Mephenytoin caused by Remimazolam mediated induction of CYP450 enzyme. |
Labour/delivery anaesthesia complication [JB0C]
|
[22] |
Methotrexate |
DM2TEOL
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Methotrexate. |
Leukaemia [2A60-2B33]
|
[34] |
PF-06463922 |
DMKM7EW
|
Moderate |
Increased metabolism of Mephenytoin caused by PF-06463922 mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[14] |
Chloroquine |
DMSI5CB
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Chloroquine. |
Malaria [1F40-1F45]
|
[14] |
Hydroxychloroquine |
DMSIVND
|
Moderate |
Antagonize the effect of Mephenytoin when combined with Hydroxychloroquine. |
Malaria [1F40-1F45]
|
[14] |
Calaspargase pegol |
DMQZBXI
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Calaspargase pegol. |
Malignant haematopoietic neoplasm [2B33]
|
[44] |
Idelalisib |
DM602WT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Idelalisib. |
Mature B-cell leukaemia [2A82]
|
[45] |
Clofarabine |
DMCVJ86
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Clofarabine. |
Mature B-cell lymphoma [2A85]
|
[46] |
Dabrafenib |
DMX6OE3
|
Moderate |
Increased metabolism of Mephenytoin caused by Dabrafenib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[34] |
Allopregnanolone |
DMNLHAC
|
Moderate |
Additive CNS depression effects by the combination of Mephenytoin and Allopregnanolone. |
Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]
|
[47] |
Lasmiditan |
DMXLVDT
|
Moderate |
Additive CNS depression effects by the combination of Mephenytoin and Lasmiditan. |
Migraine [8A80]
|
[48] |
Midazolam |
DMXOELT
|
Moderate |
Increased metabolism of Mephenytoin caused by Midazolam mediated induction of CYP450 enzyme. |
Mood/affect symptom [MB24]
|
[13] |
Thalidomide |
DM70BU5
|
Moderate |
Additive CNS depression effects by the combination of Mephenytoin and Thalidomide. |
Multiple myeloma [2A83]
|
[49] |
Ocrelizumab |
DMEZ2KH
|
Moderate |
Additive immunosuppressive effects by the combination of Mephenytoin and Ocrelizumab. |
Multiple sclerosis [8A40]
|
[50] |
Rifabutin |
DM1YBHK
|
Moderate |
Increased metabolism of Mephenytoin caused by Rifabutin mediated induction of CYP450 enzyme. |
Mycobacterium infection [1B10-1B21]
|
[51] |
Omacetaxine mepesuccinate |
DMPU2WX
|
Moderate |
Additive immunosuppressive effects by the combination of Mephenytoin and Omacetaxine mepesuccinate. |
Myeloproliferative neoplasm [2A20]
|
[52] |
Modafinil |
DMYILBE
|
Moderate |
Decreased metabolism of Mephenytoin caused by Modafinil mediated inhibition of CYP450 enzyme. |
Narcolepsy [7A20]
|
[14] |
Dextropropoxyphene |
DM23HCX
|
Major |
Additive CNS depression effects by the combination of Mephenytoin and Dextropropoxyphene. |
Pain [MG30-MG3Z]
|
[53] |
Buprenorphine |
DMPRI8G
|
Major |
Additive CNS depression effects by the combination of Mephenytoin and Buprenorphine. |
Pain [MG30-MG3Z]
|
[54] |
Abametapir |
DM2RX0I
|
Moderate |
Decreased metabolism of Mephenytoin caused by Abametapir mediated inhibition of CYP450 enzyme. |
Pediculosis [1G00]
|
[55] |
Esomeprazole |
DM7BN0X
|
Minor |
Increased plasma concentrations of Mephenytoin and Esomeprazole due to competitive inhibition of the same metabolic pathway. |
Peptic ulcer [DA61]
|
[56] |
Prednisone |
DM2HG4X
|
Moderate |
Increased metabolism of Mephenytoin caused by Prednisone mediated induction of CYP450 enzyme. |
Postoperative inflammation [1A00-CA43]
|
[43] |
Hydrocortisone |
DMGEMB7
|
Moderate |
Increased metabolism of Mephenytoin caused by Hydrocortisone mediated induction of CYP450 enzyme. |
Postoperative inflammation [1A00-CA43]
|
[43] |
Lonafarnib |
DMGM2Z6
|
Moderate |
Decreased metabolism of Mephenytoin caused by Lonafarnib mediated inhibition of CYP450 enzyme. |
Premature ageing appearance [LD2B]
|
[57] |
Ustekinumab |
DMHTYK3
|
Moderate |
Altered metabolism of Mephenytoin due to Ustekinumab alters the formation of CYP450 enzymes. |
Psoriasis [EA90]
|
[34] |
Ixekizumab |
DMXW92T
|
Moderate |
Altered metabolism of Mephenytoin due to Ixekizumab alters the formation of CYP450 enzymes. |
Psoriasis [EA90]
|
[34] |
Tocilizumab |
DM7J6OR
|
Moderate |
Altered metabolism of Mephenytoin due to Tocilizumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[34] |
Canakinumab |
DM8HLO5
|
Moderate |
Altered metabolism of Mephenytoin due to Canakinumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[34] |
Rilonacept |
DMGLUQS
|
Moderate |
Altered metabolism of Mephenytoin due to Rilonacept alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[34] |
Golimumab |
DMHZV7X
|
Moderate |
Altered metabolism of Mephenytoin due to Golimumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[34] |
Dexamethasone |
DMMWZET
|
Moderate |
Increased metabolism of Mephenytoin caused by Dexamethasone mediated induction of CYP450 enzyme. |
Rheumatoid arthritis [FA20]
|
[43] |
Sarilumab |
DMOGNXY
|
Moderate |
Altered metabolism of Mephenytoin due to Sarilumab alters the formation of CYP450 enzymes. |
Rheumatoid arthritis [FA20]
|
[34] |
Leflunomide |
DMR8ONJ
|
Major |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Leflunomide. |
Rheumatoid arthritis [FA20]
|
[39] |
Methylprednisolone |
DM4BDON
|
Moderate |
Increased metabolism of Mephenytoin caused by Methylprednisolone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[43] |
Trabectedin |
DMG3Y89
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Trabectedin. |
Solid tumour/cancer [2A00-2F9Z]
|
[34] |
Armodafinil |
DMGB035
|
Moderate |
Decreased metabolism of Mephenytoin caused by Armodafinil mediated inhibition of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[14] |
Prednisolone |
DMQ8FR2
|
Moderate |
Increased metabolism of Mephenytoin caused by Prednisolone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[43] |
Disulfiram |
DMCL2OK
|
Moderate |
Decreased metabolism of Mephenytoin caused by Disulfiram mediated inhibition of CYP450 enzyme. |
Substance abuse [6C40]
|
[58] |
Naltrexone |
DMUL45H
|
Moderate |
Increased risk of hepatotoxicity by the combination of Mephenytoin and Naltrexone. |
Substance abuse [6C40]
|
[59] |
Warfarin |
DMJYCVW
|
Moderate |
Increased metabolism of Mephenytoin caused by Warfarin mediated induction of CYP450 enzyme. |
Supraventricular tachyarrhythmia [BC81]
|
[60] |
Pipecuronium |
DM5F84A
|
Moderate |
Increased metabolism of Mephenytoin caused by Pipecuronium mediated induction of CYP450 enzyme. |
Tonus and reflex abnormality [MB47]
|
[14] |
Doxacurium |
DMKE7L9
|
Moderate |
Increased metabolism of Mephenytoin caused by Doxacurium mediated induction of CYP450 enzyme. |
Tonus and reflex abnormality [MB47]
|
[14] |
Cisatracurium |
DMUZPJ5
|
Moderate |
Increased metabolism of Mephenytoin caused by Cisatracurium mediated induction of CYP450 enzyme. |
Tonus and reflex abnormality [MB47]
|
[61] |
Rocuronium |
DMY9BMK
|
Moderate |
Increased metabolism of Mephenytoin caused by Rocuronium mediated induction of CYP450 enzyme. |
Tonus and reflex abnormality [MB47]
|
[61] |
Mycophenolate mofetil |
DMPQAGE
|
Minor |
Increased plasma concentration of Mephenytoin and Mycophenolate mofetil due to competitive binding of plasma proteins. |
Transplant rejection [NE84]
|
[30] |
Canagliflozin |
DMFRM1I
|
Moderate |
Increased metabolism of Mephenytoin caused by Canagliflozin mediated induction of UGT. |
Type 2 diabetes mellitus [5A11]
|
[14] |
Nitrofurantoin |
DM7PQIK
|
Moderate |
Increased metabolism of Mephenytoin caused by Nitrofurantoin mediated induction of CYP450 enzyme. |
Urinary tract infection [GC08]
|
[62] |
Triamcinolone |
DM98IXF
|
Moderate |
Increased metabolism of Mephenytoin caused by Triamcinolone mediated induction of CYP450 enzyme. |
Vasomotor/allergic rhinitis [CA08]
|
[43] |
----------- |
|
|
|
|
|