Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: )

• Drug Name: Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 3	[1]

• Cross-matching ID: TTD Drug ID

Molecule-Related Drug Atlas

Drug(s) Targeting Erbb2 tyrosine kinase receptor (HER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[12]
Dacomitinib	DMOH8VY	Non-small-cell lung cancer	2C25.Y	Approved	[13]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[14]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[15]
NERATINIB MALEATE	DMEDU7B	HER2/NEU overexpressing breast cancer	2C60-2C65	Approved	[16]
Margetuximab	DMKEY6S	HER2-positive breast cancer	2C60-2C65	Approved	[17]
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[18]
Tucatinib	DMBESUA	HER2-positive breast cancer	2C60-2C65	Approved	[19]
Pertuzumab	DMHJV0X	Adrenal gland neoplasm		Approved	[2]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[20]

Drug(s) Targeting Vascular endothelial growth factor A (VEGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aflibercept	DMT3D5I	Central retinal vein occlusion with macular edema		Approved	[21]
Brolucizumab	DMW8QNG	Wet age-related macular degeneration	9B78.3Z	Approved	[22]
Faricimab	DM83SEB	Diabetic macular edema	9B71.02	Approved	[23]
Ranibizumab	DMSYPNW	Central retinal vein occlusion with macular edema		Approved	[24]
Bevacizumab	DMSD1UN	Adenocarcinoma	2D40	Approved	[25]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[26]
PTC299	DMP9TKE	Rheumatoid arthritis	FA20	Phase 2	[27]
RG7221	DM8J9DC	Colorectal cancer	2B91.Z	Phase 2	[28]
RO5520985	DMD3WNP	Colorectal cancer	2B91.Z	Phase 2	[29]
Abicipar pegol	DM59OJ2	Diabetic macular edema	9B71.02	Phase 2	[30]

Drug(s) Targeting Farnesoid X-activated receptor (FXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[3]
Guggulsterone	DMP7LK1	Osteoarthritis	FA00-FA05	Approved	[31]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[32]
GS-9674	DM936V7	Primary sclerosing cholangitis	DB96.2	Phase 3	[33]
Apomine	DM6B9HP	Osteopetrosis	LD24.10	Phase 2	[34]
LJN452	DM3XRUH	Primary biliary cholangitis	DB96.1	Phase 2	[35]
EYP001	DM5PBLM	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[36]
EDP-305	DMGJYZ8	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[37]
LMB763	DMQOXNL	Diabetic nephropathy	GB61.Z	Phase 2	[38]
MET409	DM89QXT	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[39]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[42]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[43]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[43]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[41]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[56]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[41]

Drug(s) Affected By Gastrotropin (FABP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[62]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[63]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[69]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[71]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[72]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[73]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[74]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[75]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[80]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[75]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[81]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[82]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[83]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[84]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[87]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[88]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]

Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[94]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[103]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[105]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[103]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[110]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]

Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[110]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[100]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[114]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[119]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[120]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[121]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[124]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[125]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[126]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[134]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[102]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[140]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[141]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[142]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[143]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[140]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[140]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[144]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[145]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[146]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[147]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[147]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[148]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[146]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[147]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[150]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[146]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[153]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]

Drug(s) Affected By Fibroblast growth factor 19 (FGF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[11]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[161]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[11]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[171]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[172]
Fructose	DM43AN2	Vomiting	MD90	Approved	[173]
Ketoprofen	DMRKXPT	Bursitis		Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[175]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[176]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[177]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[180]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[181]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[184]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[185]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[186]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[187]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[188]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[173]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[189]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[190]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[191]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[192]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[193]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[206]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[206]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[208]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[211]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[212]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[213]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Fructose	DM43AN2	Vomiting	MD90	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[170]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[222]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[227]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[228]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[229]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[230]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[231]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[232]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[233]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[234]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[235]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[233]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[237]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[243]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[244]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[248]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[252]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[255]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[256]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[257]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[258]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[261]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[261]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[261]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[262]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[265]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[266]
Selenium	DM25CGV	N. A.	N. A.	Approved	[267]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[268]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[269]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[181]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[272]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[275]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[276]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[277]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[278]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[279]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[280]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[281]

Drug(s) Affected By Ribonuclease inhibitor (RNH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[284]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[285]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[237]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[288]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[289]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[290]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[291]

Drug(s) Affected By Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[292]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[295]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[102]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[296]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[297]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[299]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[300]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[296]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Haloperidol	DM96SE0	Delirium		Approved	[304]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[283]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[305]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[307]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[175]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[309]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[310]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[311]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[313]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[315]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[307]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[316]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[317]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[306]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[175]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[309]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[114]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[320]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[170]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[322]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[323]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[324]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[323]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[325]

Drug(s) Affected By T-complex protein 1 subunit zeta (CCT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[283]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[295]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[326]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[328]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[329]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[330]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[331]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[333]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[334]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[335]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[336]

Drug(s) Affected By Ran GTPase-activating protein 1 (RANGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[283]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[339]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[341]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[345]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[165]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[347]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[348]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[352]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[283]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[355]

Drug(s) Affected By Cathelicidin antimicrobial peptide (CAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[357]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[358]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[359]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[359]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[360]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[364]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[372]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[376]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (ST3GAL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[379]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[375]

Drug(s) Affected By Heat shock protein 75 kDa, mitochondrial (TRAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[380]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[382]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[283]

Drug(s) Affected By Calcium-activated potassium channel subunit beta-1 (KCNMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[384]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[385]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[386]

Drug(s) Affected By G-protein coupled bile acid receptor 1 (GPBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[11]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[387]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[389]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]
tauroursodeoxycholic acid	DMFKRQE	Discovery agent	N.A.	Investigative	[387]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[391]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[106]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[157]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[392]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[393]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[104]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[294]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[394]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[395]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[396]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[397]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[11]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[110]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[398]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[399]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[400]
Selenium	DM25CGV	N. A.	N. A.	Approved	[199]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[401]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[402]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[404]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[405]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[299]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[407]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[170]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[278]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[410]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[411]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[148]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[414]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[415]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[415]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[396]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[416]

Drug(s) Affected By Calcium-activated potassium channel subunit alpha-1 (KCNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[417]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[418]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[419]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[421]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[72]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[72]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[422]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[423]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[424]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[425]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[251]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[426]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[278]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[427]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[418]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Erbb2 tyrosine kinase receptor (HER2)	TT6EO5L	ERBB2_HUMAN	Not Available	[2]
Farnesoid X-activated receptor (FXR)	TTS4UGC	NR1H4_HUMAN	Antagonist	[3]
Vascular endothelial growth factor A (VEGFA)	TTOHSBA	VEGFA_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Gene/Protein Processing	[4]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[5]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[6]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[7]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Protein Interaction/Cellular Processes	[8]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[9]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[10]
ATP-binding cassette sub-family G member 5 (ABCG5)	OT1OMY93	ABCG5_HUMAN	Gene/Protein Processing	[11]

References

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• [2] Clinical pipeline report, company report or official report of Roche (2009).
• [3] Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277(35):31441-7.
• [4] The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci. 2009 May;109(1):50-8.
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• [6] Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs. J Control Release. 2010 Mar 3;142(2):206-13. doi: 10.1016/j.jconrel.2009.10.025. Epub 2009 Nov 10.
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