Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA12HB)

• Drug Name: SEP--4199 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Bipolar disorder	6A60	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMA12HB

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[2]
Haloperidol	DM96SE0	Delirium		Approved	[3]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[4]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[5]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[6]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[7]
Quetiapine	DM1N62C	Anorexia nervosa cachexia	6B80	Approved	[8]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[9]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[10]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[11]

Drug(s) Targeting 5-HT receptor (5HTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[12]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[13]
Ramosetron	DMH7GN8	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[12]
Pizotyline	DMV74ZH	Headache	8A80-8A84	Approved	[13]
Tandospirone	DMPHWU6	Anxiety disorder	6B00-6B0Z	Approved	[12]
Nafronyl	DMVMQ1L	Cerebrovascular ischaemia	8B1Z	Approved	[13]
ITI-007	DMUQ1DO	Depression	6A70-6A7Z	Phase 3	[14]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[15]
MIN-117	DMSLIW6	Major depressive disorder	6A70.3	Phase 2	[14]
Lu-AA34893	DM2ZUXK	Anxiety disorder	6B00-6B0Z	Phase 2	[16]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT receptor (5HTR)	TT85JO3	NOUNIPROTAC	Antagonist	[1]
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[1]

References

• [1] ClinicalTrials.gov (NCT03543410) A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression. U.S. National Institutes of Health.
• [2] The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74.
• [3] Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment. Synapse. 2002 Aug;45(2):78-85.
• [4] CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics. 2007 Nov;17(11):989-93.
• [5] Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands. Bioorg Med Chem. 2005 Jan 3;13(1):77-87.
• [6] Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta. 2006 Jan 15;68(3):928-31.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3639).
• [8] Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol. 2009 Apr 1;607(1-3):35-40.
• [9] [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1.
• [10] Modulatory role of dopamine D2 receptors and fundamental role of L-type Ca2+ channels in the induction of long-term potentiation in the basolateral... Eur J Pharmacol. 2009 Mar 15;606(1-3):90-3.
• [11] Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
• [12] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [13] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [14] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [15] Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418.
• [16] Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105).