Details of the Drug

General Information of Drug (ID: DMW83TP)

• Drug Name: Pimozide
• Synonyms: Antalon; Neoperidole; Opiran; Orap; Pimozida; Pimozidum; Primozida; ASTA Medica Brand of Pimozide; Janssen Brand of Pimozide;Orap forte; Pharmascience Brand of Pimozide; P 1793; R 6238; McN-JR 6238; Orap (TN); Pimozida [INN-Spanish]; Pimozidum [INN-Latin]; Primozida [INN-Spanish]; R-6238; McN-JR-6238; Pimozide (JAN/USP/INN); Pimozide [USAN:INN:BAN:JAN]; 1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone; 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone; 1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Approved	[1]
Tourette syndrome	8A05.00	Investigative	[2]

• Therapeutic Class: Antipsychotic Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 461.5
  Logarithm of the Partition Coefficient (xlogp); 6.3
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 4
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 29 +/-10 hours [4]
  Metabolism: The drug is metabolized via the liver []
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.3095 micromolar/kg/day [5]
  Water Solubility: The ability of drug to dissolve in water is measured as 0.008 mg/mL [3]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Seizures (incl subtypes)	Not Available	KCNJ3	OTHQG16J	[6]

• Chemical Identifiers:
  Formula: C28H29F2N3O
  IUPAC Name: 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
  Canonical SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
  InChI: InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
  InChIKey: YVUQSNJEYSNKRX-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 16362
  ChEBI ID: CHEBI:8212
  CAS Number: 2062-78-4
  DrugBank ID: DB01100
  TTD ID: D00KHM
  VARIDT ID: DR00484
  INTEDE ID: DR1291
  ACDINA ID: D00532
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[7]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[9]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[10]
Cytochrome P450 1A2 (CYP1A2) Main DME	DEJGDUW	CP1A2_HUMAN	Substrate	[9]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[11]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[11]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[12]
G protein-activated inward rectifier potassium channel 1 (KCNJ3)	OTHQG16J	KCNJ3_HUMAN	Drug Response	[6]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Gene/Protein Processing	[13]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Gene/Protein Processing	[14]

Molecular Expression Atlas of This Drug

• The Studied Disease: Schizophrenia
• ICD Disease Classification: 6A20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49
P-glycoprotein 1 (ABCB1)	DTP	P-GP	9.39E-02	1.07E-01	2.80E-01
Cytochrome P450 1A2 (CYP1A2)	DME	CYP1A2	7.36E-01	1.62E-02	1.08E-01
Cytochrome P450 3A5 (CYP3A5)	DME	CYP3A5	9.96E-01	-3.17E-03	-1.84E-02
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	7.30E-01	-1.91E-02	-1.41E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	1.04E-02	6.29E-02	3.54E-01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Pimozide

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Quetiapine	DM1N62C	Major	Increased risk of prolong QT interval by the combination of Pimozide and Quetiapine.	Schizophrenia [6A20]	[15]
Aripiprazole	DM3NUMH	Moderate	Additive anticholinergic effects by the combination of Pimozide and Aripiprazole.	Schizophrenia [6A20]	[16]
Iloperidone	DM6AUFY	Major	Increased risk of prolong QT interval by the combination of Pimozide and Iloperidone.	Schizophrenia [6A20]	[15]
Paliperidone	DM7NPJS	Major	Increased risk of prolong QT interval by the combination of Pimozide and Paliperidone.	Schizophrenia [6A20]	[15]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Pimozide and Molindone.	Schizophrenia [6A20]	[16]
Amisulpride	DMSJVAM	Major	Increased risk of prolong QT interval by the combination of Pimozide and Amisulpride.	Schizophrenia [6A20]	[15]
Asenapine	DMSQZE2	Major	Increased risk of prolong QT interval by the combination of Pimozide and Asenapine.	Schizophrenia [6A20]	[15]

Coadministration of a Drug Treating the Disease Different from Pimozide (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Ivosidenib	DM8S6T7	Major	Increased risk of prolong QT interval by the combination of Pimozide and Ivosidenib.	Acute myeloid leukaemia [2A60]	[15]
Midostaurin	DMI6E0R	Major	Increased risk of prolong QT interval by the combination of Pimozide and Midostaurin.	Acute myeloid leukaemia [2A60]	[15]
Idarubicin	DMM0XGL	Major	Increased risk of prolong QT interval by the combination of Pimozide and Idarubicin.	Acute myeloid leukaemia [2A60]	[15]
Arn-509	DMT81LZ	Major	Increased risk of prolong QT interval by the combination of Pimozide and Arn-509.	Acute myeloid leukaemia [2A60]	[15]
Gilteritinib	DMTI0ZO	Major	Increased risk of prolong QT interval by the combination of Pimozide and Gilteritinib.	Acute myeloid leukaemia [2A60]	[15]
Oliceridine	DM6MDCF	Major	Increased risk of prolong QT interval by the combination of Pimozide and Oliceridine.	Acute pain [MG31]	[15]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Pimozide and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[17]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Pimozide and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[17]
Ivabradine	DM0L594	Major	Increased risk of ventricular arrhythmias by the combination of Pimozide and Ivabradine.	Angina pectoris [BA40]	[15]
Bepridil	DM0RKS4	Major	Increased risk of prolong QT interval by the combination of Pimozide and Bepridil.	Angina pectoris [BA40]	[15]
Dronedarone	DMA8FS5	Major	Increased risk of prolong QT interval by the combination of Pimozide and Dronedarone.	Angina pectoris [BA40]	[18]
Nifedipine	DMSVOZT	Major	Decreased metabolism of Pimozide caused by Nifedipine mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[19]
Bedaquiline	DM3906J	Major	Increased risk of prolong QT interval by the combination of Pimozide and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[15]
Cilostazol	DMZMSCT	Major	Increased risk of prolong QT interval by the combination of Pimozide and Cilostazol.	Arterial occlusive disease [BD40]	[15]
Posaconazole	DMUL5EW	Major	Decreased metabolism of Pimozide caused by Posaconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[19]
Levalbuterol	DM5YBO1	Moderate	Increased risk of prolong QT interval by the combination of Pimozide and Levalbuterol.	Asthma [CA23]	[20]
Pirbuterol	DMI5678	Moderate	Increased risk of ventricular arrhythmias by the combination of Pimozide and Pirbuterol.	Asthma [CA23]	[21]
Lisdexamfetamine	DM6W8V5	Major	Increased risk of prolong QT interval by the combination of Pimozide and Lisdexamfetamine.	Attention deficit hyperactivity disorder [6A05]	[15]
Obeticholic acid	DM3Q1SM	Moderate	Decreased metabolism of Pimozide caused by Obeticholic acid mediated inhibition of CYP450 enzyme.	Autoimmune liver disease [DB96]	[22]
Ofloxacin	DM0VQN3	Major	Increased risk of prolong QT interval by the combination of Pimozide and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Dalfopristin	DM4LTKV	Major	Decreased metabolism of Pimozide caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[23]
Clarithromycin	DM4M1SG	Major	Decreased metabolism of Pimozide caused by Clarithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[24]
Sparfloxacin	DMB4HCT	Major	Increased risk of prolong QT interval by the combination of Pimozide and Sparfloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Gemifloxacin	DMHT34O	Major	Increased risk of prolong QT interval by the combination of Pimozide and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Levofloxacin	DMS60RB	Major	Increased risk of prolong QT interval by the combination of Pimozide and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[15]
Troleandomycin	DMUZNIG	Major	Decreased metabolism of Pimozide caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[24]
Retigabine	DMGNYIH	Major	Increased risk of prolong QT interval by the combination of Pimozide and Retigabine.	Behcet disease [4A62]	[15]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Pimozide and Cariprazine.	Bipolar disorder [6A60]	[16]
Erdafitinib	DMI782S	Moderate	Increased metabolism of Pimozide caused by Erdafitinib mediated induction of CYP450 enzyme.	Bladder cancer [2C94]	[25]
Eribulin	DM1DX4Q	Major	Increased risk of prolong QT interval by the combination of Pimozide and Eribulin.	Breast cancer [2C60-2C6Y]	[15]
Palbociclib	DMD7L94	Moderate	Decreased metabolism of Pimozide caused by Palbociclib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[19]
Bosutinib	DMTI8YE	Major	Increased risk of prolong QT interval by the combination of Pimozide and Bosutinib.	Breast cancer [2C60-2C6Y]	[15]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Pimozide when combined with Acetylcholine.	Cataract [9B10]	[26]
PF-04449913	DMSB068	Major	Increased risk of prolong QT interval by the combination of Pimozide and PF-04449913.	Chronic myelomonocytic leukaemia [2A40]	[15]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Pimozide and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[27]
Olodaterol	DM62B78	Moderate	Increased risk of prolong QT interval by the combination of Pimozide and Olodaterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Vilanterol	DMF5EK1	Moderate	Increased risk of ventricular arrhythmias by the combination of Pimozide and Vilanterol.	Chronic obstructive pulmonary disease [CA22]	[20]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Pimozide and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[27]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Pimozide and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[27]
Indacaterol	DMQJHR7	Moderate	Increased risk of ventricular arrhythmias by the combination of Pimozide and Indacaterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Arformoterol	DMYM974	Moderate	Increased risk of ventricular arrhythmias by the combination of Pimozide and Arformoterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Dihydrocodeine	DMB0FWL	Major	Additive CNS depression effects by the combination of Pimozide and Dihydrocodeine.	Chronic pain [MG30]	[28]
Panitumumab	DMQPD1F	Major	Increased risk of ventricular arrhythmias by the combination of Pimozide and Panitumumab.	Colorectal cancer [2B91]	[29]
Halothane	DM80OZ5	Major	Increased risk of prolong QT interval by the combination of Pimozide and Halothane.	Corneal disease [9A76-9A78]	[15]
Sevoflurane	DMC9O43	Major	Increased risk of prolong QT interval by the combination of Pimozide and Sevoflurane.	Corneal disease [9A76-9A78]	[15]
Probucol	DMVZQ2M	Major	Increased risk of prolong QT interval by the combination of Pimozide and Probucol.	Coronary atherosclerosis [BA80]	[15]
Pasireotide	DMHM7JS	Major	Increased risk of prolong QT interval by the combination of Pimozide and Pasireotide.	Cushing syndrome [5A70]	[15]
Osilodrostat	DMIJC9X	Major	Increased risk of prolong QT interval by the combination of Pimozide and Osilodrostat.	Cushing syndrome [5A70]	[15]
MK-8228	DMOB58Q	Major	Decreased metabolism of Pimozide caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[19]
Sertraline	DM0FB1J	Major	Increased risk of prolong QT interval by the combination of Pimozide and Sertraline.	Depression [6A70-6A7Z]	[30]
Nefazodone	DM4ZS8M	Major	Decreased metabolism of Pimozide caused by Nefazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[19]
Escitalopram	DMFK9HG	Major	Increased risk of prolong QT interval by the combination of Pimozide and Escitalopram.	Depression [6A70-6A7Z]	[18]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Pimozide and OPC-34712.	Depression [6A70-6A7Z]	[16]
Clomipramine	DMINRKW	Major	Increased risk of prolong QT interval by the combination of Pimozide and Clomipramine.	Depression [6A70-6A7Z]	[15]
Doxepin	DMPI98T	Major	Increased risk of prolong QT interval by the combination of Pimozide and Doxepin.	Depression [6A70-6A7Z]	[15]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Pimozide and Esketamine.	Depression [6A70-6A7Z]	[19]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Pimozide and Mepenzolate.	Digestive system disease [DE2Z]	[16]
Tetrabenazine	DMYWQ0O	Major	Increased risk of prolong QT interval by the combination of Pimozide and Tetrabenazine.	Dissociative neurological symptom disorder [6B60]	[15]
Deutetrabenazine	DMUPFLI	Major	Increased risk of prolong QT interval by the combination of Pimozide and Deutetrabenazine.	Dystonic disorder [8A02]	[15]
Ingrezza	DMVPLNC	Major	Increased risk of prolong QT interval by the combination of Pimozide and Ingrezza.	Dystonic disorder [8A02]	[15]
Stiripentol	DMMSDOY	Major	Decreased metabolism of Pimozide caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[19]
Rufinamide	DMWE60C	Moderate	Increased metabolism of Pimozide caused by Rufinamide mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[15]
Solifenacin	DMG592Q	Major	Increased risk of prolong QT interval by the combination of Pimozide and Solifenacin.	Functional bladder disorder [GC50]	[15]
Mirabegron	DMS1GYT	Major	Decreased metabolism of Pimozide caused by Mirabegron mediated inhibition of CYP450 enzyme.	Functional bladder disorder [GC50]	[18]
Itraconazole	DMCR1MV	Major	Decreased metabolism of Pimozide caused by Itraconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Miconazole	DMPMYE8	Moderate	Decreased metabolism of Pimozide caused by Miconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[31]
Sunitinib	DMCBJSR	Major	Increased risk of prolong QT interval by the combination of Pimozide and Sunitinib.	Gastrointestinal stromal tumour [2B5B]	[15]
Dichlorphenamide	DMH7IDQ	Major	Increased risk of ventricular arrhythmias by the combination of Pimozide and Dichlorphenamide.	Glaucoma [9C61]	[31]
Telaprevir	DMMRV29	Major	Decreased metabolism of Pimozide caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[19]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Pimozide caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[32]
Fosamprenavir	DM4W9B3	Major	Decreased metabolism of Pimozide caused by Fosamprenavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Fostemsavir	DM50ILT	Major	Increased risk of prolong QT interval by the combination of Pimozide and Fostemsavir.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Saquinavir	DMG814N	Major	Decreased metabolism of Pimozide caused by Saquinavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Etravirine	DMGV8QU	Moderate	Increased metabolism of Pimozide caused by Etravirine mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[33]
Rilpivirine	DMJ0QOW	Major	Increased risk of prolong QT interval by the combination of Pimozide and Rilpivirine.	Human immunodeficiency virus disease [1C60-1C62]	[15]
Darunavir	DMN3GCH	Major	Decreased metabolism of Pimozide caused by Darunavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
BMS-201038	DMQTAGO	Major	Decreased metabolism of Pimozide caused by BMS-201038 mediated inhibition of CYP450 enzyme.	Hyper-lipoproteinaemia [5C80]	[19]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Pimozide and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[16]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Pimozide caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[34]
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Pimozide and ITI-007.	Insomnia [7A00-7A0Z]	[16]
Polyethylene glycol	DM4I1JP	Major	Increased risk of ventricular arrhythmias by the combination of Pimozide and Polyethylene glycol.	Irritable bowel syndrome [DD91]	[35]
Phenolphthalein	DM5SICT	Moderate	Increased risk of ventricular arrhythmias by the combination of Pimozide and Phenolphthalein.	Irritable bowel syndrome [DD91]	[18]
Glycerol phenylbutyrate	DMDGRQO	Moderate	Increased metabolism of Pimozide caused by Glycerol phenylbutyrate mediated induction of CYP450 enzyme.	Liver disease [DB90-DB9Z]	[15]
Crizotinib	DM4F29C	Major	Increased risk of prolong QT interval by the combination of Pimozide and Crizotinib.	Lung cancer [2C25]	[15]
Brigatinib	DM7W94S	Moderate	Increased metabolism of Pimozide caused by Brigatinib mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[36]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Pimozide caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[37]
Dacomitinib	DMOH8VY	Major	Decreased metabolism of Pimozide caused by Dacomitinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[18]
Osimertinib	DMRJLAT	Major	Increased risk of prolong QT interval by the combination of Pimozide and Osimertinib.	Lung cancer [2C25]	[15]
Selpercatinib	DMZR15V	Major	Increased risk of prolong QT interval by the combination of Pimozide and Selpercatinib.	Lung cancer [2C25]	[15]
Halofantrine	DMOMK1V	Major	Increased risk of prolong QT interval by the combination of Pimozide and Halofantrine.	Malaria [1F40-1F45]	[38]
Hydroxychloroquine	DMSIVND	Major	Increased risk of prolong QT interval by the combination of Pimozide and Hydroxychloroquine.	Malaria [1F40-1F45]	[15]
Inotuzumab ozogamicin	DMAC130	Major	Increased risk of prolong QT interval by the combination of Pimozide and Inotuzumab ozogamicin.	Malignant haematopoietic neoplasm [2B33]	[15]
Idelalisib	DM602WT	Major	Decreased metabolism of Pimozide caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[19]
IPI-145	DMWA24P	Major	Decreased metabolism of Pimozide caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[19]
Arsenic trioxide	DM61TA4	Major	Increased risk of prolong QT interval by the combination of Pimozide and Arsenic trioxide.	Mature B-cell lymphoma [2A85]	[15]
Vemurafenib	DM62UG5	Major	Increased risk of prolong QT interval by the combination of Pimozide and Vemurafenib.	Melanoma [2C30]	[15]
LGX818	DMNQXV8	Major	Increased risk of prolong QT interval by the combination of Pimozide and LGX818.	Melanoma [2C30]	[15]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Pimozide caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[15]
Danazol	DML8KTN	Major	Decreased metabolism of Pimozide caused by Danazol mediated inhibition of CYP450 enzyme.	Menstrual cycle bleeding disorder [GA20]	[19]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Pimozide and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[39]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Pimozide and Lasmiditan.	Migraine [8A80]	[40]
Exjade	DMHPRWG	Moderate	Decreased metabolism of Pimozide caused by Exjade mediated inhibition of CYP450 enzyme.	Mineral absorption/transport disorder [5C64]	[41]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Pimozide and Flibanserin.	Mood disorder [6A60-6E23]	[42]
Panobinostat	DM58WKG	Major	Increased risk of prolong QT interval by the combination of Pimozide and Panobinostat.	Multiple myeloma [2A83]	[15]
Fingolimod	DM5JVAN	Major	Increased risk of ventricular arrhythmias by the combination of Pimozide and Fingolimod.	Multiple sclerosis [8A40]	[18]
Ozanimod	DMT6AM2	Major	Increased risk of prolong QT interval by the combination of Pimozide and Ozanimod.	Multiple sclerosis [8A40]	[15]
Romidepsin	DMT5GNL	Major	Increased risk of prolong QT interval by the combination of Pimozide and Romidepsin.	Mycosis fungoides [2B01]	[15]
Fedratinib	DM4ZBK6	Major	Decreased metabolism of Pimozide caused by Fedratinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[19]
Nilotinib	DM7HXWT	Major	Increased risk of prolong QT interval by the combination of Pimozide and Nilotinib.	Myeloproliferative neoplasm [2A20]	[15]
Dasatinib	DMJV2EK	Major	Increased risk of prolong QT interval by the combination of Pimozide and Dasatinib.	Myeloproliferative neoplasm [2A20]	[15]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Pimozide and Phenindamine.	Nasopharyngitis [CA00]	[16]
Rolapitant	DM8XP26	Major	Decreased metabolism of Pimozide caused by Rolapitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[18]
Cyclizine	DM9G7BS	Moderate	Additive anticholinergic effects by the combination of Pimozide and Cyclizine.	Nausea/vomiting [MD90]	[16]
Metoclopramide	DMFA5MY	Major	Additive antidopaminergic effects by the combination of Pimozide and Metoclopramide.	Nausea/vomiting [MD90]	[43]
Bupropion	DM5PCS7	Major	Decreased metabolism of Pimozide caused by Bupropion mediated inhibition of CYP450 enzyme.	Nicotine use disorder [6C4A]	[18]
Entrectinib	DMMPTLH	Major	Increased risk of prolong QT interval by the combination of Pimozide and Entrectinib.	Non-small cell lung cancer [2C25]	[15]
Lorcaserin	DMG6OYJ	Major	Decreased metabolism of Pimozide caused by Lorcaserin mediated inhibition of CYP450 enzyme.	Obesity [5B80-5B81]	[18]
Polythiazide	DMCH80F	Major	Increased risk of ventricular arrhythmias by the combination of Pimozide and Polythiazide.	Oedema [MG29]	[29]
Levomethadyl Acetate	DM06HG5	Major	Increased risk of prolong QT interval by the combination of Pimozide and Levomethadyl Acetate.	Opioid use disorder [6C43]	[15]
Lofexidine	DM1WXA6	Major	Increased risk of prolong QT interval by the combination of Pimozide and Lofexidine.	Opioid use disorder [6C43]	[15]
Olaparib	DM8QB1D	Moderate	Decreased clearance of Pimozide due to the transporter inhibition by Olaparib.	Ovarian cancer [2C73]	[19]
Rucaparib	DM9PVX8	Major	Increased risk of prolong QT interval by the combination of Pimozide and Rucaparib.	Ovarian cancer [2C73]	[15]
Oxymorphone	DM65AGJ	Major	Additive CNS depression effects by the combination of Pimozide and Oxymorphone.	Pain [MG30-MG3Z]	[44]
Dezocine	DMJDB0Y	Major	Additive CNS depression effects by the combination of Pimozide and Dezocine.	Pain [MG30-MG3Z]	[44]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Pimozide and Flavoxate.	Pain [MG30-MG3Z]	[16]
Triclabendazole	DMPWGBR	Major	Increased risk of prolong QT interval by the combination of Pimozide and Triclabendazole.	Parasitic worm infestation [1F90]	[15]
Pergolide	DM14MAE	Moderate	Additive CNS depression effects by the combination of Pimozide and Pergolide.	Parkinsonism [8A00]	[45]
Opicapone	DM1BKA6	Moderate	Additive CNS depression effects by the combination of Pimozide and Opicapone.	Parkinsonism [8A00]	[45]
Levodopa	DMN3E57	Moderate	Antagonize the effect of Pimozide when combined with Levodopa.	Parkinsonism [8A00]	[45]
Pimavanserin	DMR7IVC	Major	Increased risk of prolong QT interval by the combination of Pimozide and Pimavanserin.	Parkinsonism [8A00]	[15]
Bromocriptine	DMVE3TK	Moderate	Antagonize the effect of Pimozide when combined with Bromocriptine.	Parkinsonism [8A00]	[45]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Pimozide and Orphenadrine.	Parkinsonism [8A00]	[16]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Pimozide caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[46]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Pimozide and Methylscopolamine.	Peptic ulcer [DA61]	[16]
Macimorelin	DMQYJIR	Major	Increased risk of prolong QT interval by the combination of Pimozide and Macimorelin.	Pituitary gland disorder [5A60-5A61]	[47]
Lefamulin	DME6G97	Major	Increased risk of prolong QT interval by the combination of Pimozide and Lefamulin.	Pneumonia [CA40]	[15]
Lonafarnib	DMGM2Z6	Major	Decreased metabolism of Pimozide caused by Lonafarnib mediated inhibition of CYP450 enzyme.	Premature ageing appearance [LD2B]	[19]
Degarelix	DM3O8QY	Major	Increased risk of prolong QT interval by the combination of Pimozide and Degarelix.	Prostate cancer [2C82]	[15]
ABIRATERONE	DM8V75C	Major	Decreased metabolism of Pimozide caused by ABIRATERONE mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[18]
Enzalutamide	DMGL19D	Major	Increased risk of prolong QT interval by the combination of Pimozide and Enzalutamide.	Prostate cancer [2C82]	[15]
Relugolix	DMK7IWL	Major	Increased risk of prolong QT interval by the combination of Pimozide and Relugolix.	Prostate cancer [2C82]	[15]
Bicalutamide	DMZMSPF	Major	Decreased metabolism of Pimozide caused by Bicalutamide mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[19]
Levomepromazine	DMIKFEL	Major	Increased risk of prolong QT interval by the combination of Pimozide and Levomepromazine.	Psychotic disorder [6A20-6A25]	[15]
Neupro	DMHEAB1	Moderate	Antagonize the effect of Pimozide when combined with Neupro.	Restless legs syndrome [7A80]	[45]
Voxelotor	DMCS6M5	Major	Decreased metabolism of Pimozide caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[19]
Larotrectinib	DM26CQR	Major	Decreased metabolism of Pimozide caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[19]
Armodafinil	DMGB035	Minor	Increased metabolism of Pimozide caused by Armodafinil mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[48]
LEE011	DMMX75K	Major	Increased risk of prolong QT interval by the combination of Pimozide and LEE011.	Solid tumour/cancer [2A00-2F9Z]	[15]
Vandetanib	DMRICNP	Major	Increased risk of prolong QT interval by the combination of Pimozide and Vandetanib.	Solid tumour/cancer [2A00-2F9Z]	[15]
Triptorelin	DMTK4LS	Major	Increased risk of prolong QT interval by the combination of Pimozide and Triptorelin.	Solid tumour/cancer [2A00-2F9Z]	[15]
Pitolisant	DM8RFNJ	Major	Increased risk of prolong QT interval by the combination of Pimozide and Pitolisant.	Somnolence [MG42]	[15]
Telavancin	DM58VQX	Major	Increased risk of prolong QT interval by the combination of Pimozide and Telavancin.	Staphylococcal/streptococcal disease [1B5Y]	[15]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Pimozide caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[49]
Brilinta	DMBR01X	Moderate	Decreased metabolism of Pimozide caused by Brilinta mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[15]
Lenvatinib	DMB1IU4	Major	Increased risk of prolong QT interval by the combination of Pimozide and Lenvatinib.	Thyroid cancer [2D10]	[15]
Cabozantinib	DMIYDT4	Major	Increased risk of prolong QT interval by the combination of Pimozide and Cabozantinib.	Thyroid cancer [2D10]	[15]
Trimeprazine	DMEMV9D	Major	Increased risk of prolong QT interval by the combination of Pimozide and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[15]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Pimozide and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[16]
Propafenone	DMPIBJK	Major	Increased risk of prolong QT interval by the combination of Pimozide and Propafenone.	Ventricular tachyarrhythmia [BC71]	[15]
Flecainide	DMSQDLE	Major	Increased risk of prolong QT interval by the combination of Pimozide and Flecainide.	Ventricular tachyarrhythmia [BC71]	[15]
Amiodarone	DMUTEX3	Major	Increased risk of prolong QT interval by the combination of Pimozide and Amiodarone.	Ventricular tachyarrhythmia [BC71]	[15]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Calcium stearate	E00244	15324	lubricant

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Pimozide 1 mg tablet	1 mg	Oral Tablet	Oral
Pimozide 2 mg tablet	2 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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