Details of the Drug

General Information of Drug (ID: DM6AUFY)

Drug Name
Iloperidone
Synonyms
Fanapt; Fanapta; Fiapta; Zomaril; HP 873; Fanapt (TN); HP-873; ILO-522; Iloperidone [USAN:INN]; Fanapta, Zomaril, Iloperidone; Iloperidone (USAN/INN); 1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone; 4'-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 426.5
Logarithm of the Partition Coefficient (xlogp) 4.1
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2-4 h []
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [2]
Elimination
0.5% of drug is excreted from urine in the unchanged form [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 18 - 33 hours [3]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.804 micromolar/kg/day [4]
Vd
The volume of distribution (Vd) of drug is 1340-2800 L []
Water Solubility
The ability of drug to dissolve in water is measured as 0.03 mg/mL [2]
Chemical Identifiers
Formula
C24H27FN2O4
IUPAC Name
1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone
Canonical SMILES
CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
InChI
InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
InChIKey
XMXHEBAFVSFQEX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
71360
ChEBI ID
CHEBI:65173
CAS Number
133454-47-4
DrugBank ID
DB04946
TTD ID
D0M8VE
INTEDE ID
DR0856
ACDINA ID
D00323

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Antagonist [5]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 2D6 (CYP2D6)
Main DME 		DECB0K3 CP2D6_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [8]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Schizophrenia
ICD Disease Classification 6A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 9.96E-01 -3.17E-03 -1.84E-02
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 7.30E-01 -1.91E-02 -1.41E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Iloperidone
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Iloperidone and Amisulpride. Schizophrenia [6A20] [10]
Asenapine DMSQZE2 Major Increased risk of prolong QT interval by the combination of Iloperidone and Asenapine. Schizophrenia [6A20] [10]
Coadministration of a Drug Treating the Disease Different from Iloperidone (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Iloperidone and Ivosidenib. Acute myeloid leukaemia [2A60] [10]
Midostaurin DMI6E0R Major Increased risk of prolong QT interval by the combination of Iloperidone and Midostaurin. Acute myeloid leukaemia [2A60] [10]
Arn-509 DMT81LZ Major Increased risk of prolong QT interval by the combination of Iloperidone and Arn-509. Acute myeloid leukaemia [2A60] [10]
Gilteritinib DMTI0ZO Major Increased risk of prolong QT interval by the combination of Iloperidone and Gilteritinib. Acute myeloid leukaemia [2A60] [10]
Oliceridine DM6MDCF Major Increased risk of prolong QT interval by the combination of Iloperidone and Oliceridine. Acute pain [MG31] [10]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Iloperidone and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [11]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Iloperidone and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [11]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Iloperidone and Ivabradine. Angina pectoris [BA40] [12]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Iloperidone and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [10]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Iloperidone and Levalbuterol. Asthma [CA23] [13]
Troleandomycin DMUZNIG Major Decreased metabolism of Iloperidone caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [14]
Retigabine DMGNYIH Major Increased risk of prolong QT interval by the combination of Iloperidone and Retigabine. Behcet disease [4A62] [10]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Iloperidone and Cariprazine. Bipolar disorder [6A60] [15]
Eribulin DM1DX4Q Major Increased risk of prolong QT interval by the combination of Iloperidone and Eribulin. Breast cancer [2C60-2C6Y] [10]
Tucatinib DMBESUA Major Decreased metabolism of Iloperidone caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [14]
Bosutinib DMTI8YE Major Increased risk of prolong QT interval by the combination of Iloperidone and Bosutinib. Breast cancer [2C60-2C6Y] [10]
PF-04449913 DMSB068 Major Increased risk of prolong QT interval by the combination of Iloperidone and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [10]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Iloperidone and Olodaterol. Chronic obstructive pulmonary disease [CA22] [16]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Iloperidone and Vilanterol. Chronic obstructive pulmonary disease [CA22] [13]
Indacaterol DMQJHR7 Moderate Increased risk of ventricular arrhythmias by the combination of Iloperidone and Indacaterol. Chronic obstructive pulmonary disease [CA22] [16]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Iloperidone and Pasireotide. Cushing syndrome [5A70] [10]
Osilodrostat DMIJC9X Major Increased risk of prolong QT interval by the combination of Iloperidone and Osilodrostat. Cushing syndrome [5A70] [10]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Iloperidone caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [17]
MK-8228 DMOB58Q Moderate Decreased metabolism of Iloperidone caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [18]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Iloperidone and OPC-34712. Depression [6A70-6A7Z] [15]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Iloperidone and Esketamine. Depression [6A70-6A7Z] [19]
Deutetrabenazine DMUPFLI Major Additive antidopaminergic effects by the combination of Iloperidone and Deutetrabenazine. Dystonic disorder [8A02] [20]
Ingrezza DMVPLNC Major Increased risk of prolong QT interval by the combination of Iloperidone and Ingrezza. Dystonic disorder [8A02] [10]
Mirabegron DMS1GYT Moderate Decreased metabolism of Iloperidone caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [21]
Boceprevir DMBSHMF Major Decreased metabolism of Iloperidone caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [14]
Telaprevir DMMRV29 Major Decreased metabolism of Iloperidone caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [14]
Fostemsavir DM50ILT Major Increased risk of prolong QT interval by the combination of Iloperidone and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [10]
Cobicistat DM6L4H2 Major Decreased metabolism of Iloperidone caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [14]
Rilpivirine DMJ0QOW Major Increased risk of prolong QT interval by the combination of Iloperidone and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [10]
Levamlodipine DM92S6N Moderate Additive hypotensive effects by the combination of Iloperidone and Levamlodipine. Hypertension [BA00-BA04] [22]
TAK-491 DMCF6SX Moderate Additive hypotensive effects by the combination of Iloperidone and TAK-491. Hypertension [BA00-BA04] [22]
Givosiran DM5PFIJ Moderate Decreased metabolism of Iloperidone caused by Givosiran mediated inhibition of CYP450 enzyme. Inborn porphyrin/heme metabolism error [5C58] [23]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Iloperidone and Belladonna. Infectious gastroenteritis/colitis [1A40] [15]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Iloperidone caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [24]
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Iloperidone and ITI-007. Insomnia [7A00-7A0Z] [15]
Polyethylene glycol DM4I1JP Moderate Increased risk of ventricular arrhythmias by the combination of Iloperidone and Polyethylene glycol. Irritable bowel syndrome [DD91] [10]
Glycerol phenylbutyrate DMDGRQO Moderate Decreased metabolism of Iloperidone caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme. Liver disease [DB90-DB9Z] [12]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Iloperidone and Crizotinib. Lung cancer [2C25] [10]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Iloperidone and Ceritinib. Lung cancer [2C25] [10]
PF-06463922 DMKM7EW Moderate Increased metabolism of Iloperidone caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [25]
Dacomitinib DMOH8VY Major Decreased metabolism of Iloperidone caused by Dacomitinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [14]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Iloperidone and Osimertinib. Lung cancer [2C25] [10]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Iloperidone and Selpercatinib. Lung cancer [2C25] [10]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Iloperidone and Lumefantrine. Malaria [1F40-1F45] [19]
Inotuzumab ozogamicin DMAC130 Major Increased risk of prolong QT interval by the combination of Iloperidone and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [10]
Idelalisib DM602WT Major Decreased metabolism of Iloperidone caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [14]
IPI-145 DMWA24P Moderate Decreased metabolism of Iloperidone caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [26]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Iloperidone and Vemurafenib. Melanoma [2C30] [10]
LGX818 DMNQXV8 Major Increased risk of prolong QT interval by the combination of Iloperidone and LGX818. Melanoma [2C30] [10]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Iloperidone caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [12]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Iloperidone and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [27]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Iloperidone and Lasmiditan. Migraine [8A80] [28]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Iloperidone and Panobinostat. Multiple myeloma [2A83] [10]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Iloperidone and Siponimod. Multiple sclerosis [8A40] [19]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Iloperidone and Fingolimod. Multiple sclerosis [8A40] [10]
Ozanimod DMT6AM2 Major Increased risk of prolong QT interval by the combination of Iloperidone and Ozanimod. Multiple sclerosis [8A40] [10]
Romidepsin DMT5GNL Major Increased risk of prolong QT interval by the combination of Iloperidone and Romidepsin. Mycosis fungoides [2B01] [10]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Iloperidone caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [12]
Rolapitant DM8XP26 Moderate Decreased metabolism of Iloperidone caused by Rolapitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [29]
Entrectinib DMMPTLH Major Increased risk of prolong QT interval by the combination of Iloperidone and Entrectinib. Non-small cell lung cancer [2C25] [10]
Lofexidine DM1WXA6 Major Increased risk of prolong QT interval by the combination of Iloperidone and Lofexidine. Opioid use disorder [6C43] [10]
Rucaparib DM9PVX8 Major Increased risk of prolong QT interval by the combination of Iloperidone and Rucaparib. Ovarian cancer [2C73] [10]
Triclabendazole DMPWGBR Major Increased risk of prolong QT interval by the combination of Iloperidone and Triclabendazole. Parasitic worm infestation [1F90] [10]
Opicapone DM1BKA6 Moderate Antagonize the effect of Iloperidone when combined with Opicapone. Parkinsonism [8A00] [30]
Pimavanserin DMR7IVC Major Increased risk of prolong QT interval by the combination of Iloperidone and Pimavanserin. Parkinsonism [8A00] [10]
Abametapir DM2RX0I Moderate Decreased metabolism of Iloperidone caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [31]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Iloperidone and Methylscopolamine. Peptic ulcer [DA61] [15]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Iloperidone and Macimorelin. Pituitary gland disorder [5A60-5A61] [32]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Iloperidone and Lefamulin. Pneumonia [CA40] [33]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Iloperidone caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [14]
Degarelix DM3O8QY Major Increased risk of prolong QT interval by the combination of Iloperidone and Degarelix. Prostate cancer [2C82] [10]
ABIRATERONE DM8V75C Major Increased risk of prolong QT interval by the combination of Iloperidone and ABIRATERONE. Prostate cancer [2C82] [10]
Enzalutamide DMGL19D Major Increased risk of prolong QT interval by the combination of Iloperidone and Enzalutamide. Prostate cancer [2C82] [10]
Relugolix DMK7IWL Major Increased risk of prolong QT interval by the combination of Iloperidone and Relugolix. Prostate cancer [2C82] [10]
Neupro DMHEAB1 Moderate Antagonize the effect of Iloperidone when combined with Neupro. Restless legs syndrome [7A80] [30]
Larotrectinib DM26CQR Moderate Decreased metabolism of Iloperidone caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [19]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Iloperidone and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [10]
Triptorelin DMTK4LS Major Increased risk of prolong QT interval by the combination of Iloperidone and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [10]
Pitolisant DM8RFNJ Major Increased risk of prolong QT interval by the combination of Iloperidone and Pitolisant. Somnolence [MG42] [10]
Telavancin DM58VQX Major Increased risk of prolong QT interval by the combination of Iloperidone and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [10]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Iloperidone caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [34]
Lenvatinib DMB1IU4 Major Increased risk of prolong QT interval by the combination of Iloperidone and Lenvatinib. Thyroid cancer [2D10] [10]
Cabozantinib DMIYDT4 Major Increased risk of prolong QT interval by the combination of Iloperidone and Cabozantinib. Thyroid cancer [2D10] [10]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Iloperidone and Acrivastine. Vasomotor/allergic rhinitis [CA08] [15]
⏷ Show the Full List of 89 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Crospovidone E00626 Not Available Disintegrant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium bicarbonate E00424 516892 Alkalizing agent; Diluent
Water E00035 962 Solvent
⏷ Show the Full List of 6 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Iloperidone 1 mg tablet 1 mg Oral Tablet Oral
Iloperidone 10 mg tablet 10 mg Oral Tablet Oral
Iloperidone 12 mg tablet 12 mg Oral Tablet Oral
Iloperidone 2 mg tablet 2 mg Oral Tablet Oral
Iloperidone 4 mg tablet 4 mg Oral Tablet Oral
Iloperidone 6 mg tablet 6 mg Oral Tablet Oral
Iloperidone 8 mg tablet 8 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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4 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
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6 Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis. Acta Pharmacol Sin. 2016 Nov;37(11):1499-1508.
7 Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone. J Pharmacol Exp Ther. 1998 Sep;286(3):1285-93.
8 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
9 Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy. Toxicol Appl Pharmacol. 2020 Nov 1;406:115239. doi: 10.1016/j.taap.2020.115239. Epub 2020 Sep 14.
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27 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
28 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
29 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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