Details of the Drug

General Information of Drug (ID: DMA4MRX)

Drug Name
Perphenazine
Synonyms
Chlorperphenazine; Chlorpiprazine; Decentan; Emesinal; Etaperazin; Etaperazine; Ethaperazine; Fentazin;PZC; Perfenazina; Perfenazine; Perphenan; Perphenazin; Perphenazinum; Thilatazin; Tranquisan; Trifaron; Trilafon; Trilifan; Triphenot; Perfenazina [Italian]; Perphenazine [Trilafon]; Perphenazine maleate; P 6402; Sch 3940; Apo-Perphenazine; F-mon; Perfenazina [INN-Spanish]; Perphenazinum [INN-Latin]; SCH-3940; Siquil (TN); Triavil (TN); Perphenazine [INN:BAN:JAN]; Perphenazine (JP15/USP/INN); Gamma-[4-(beta-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine; Gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine; 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina; 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina [Italian]; 1-(2-Hydroxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine; 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine; 1-Piperazineethanol, 4-[3-(2-chlorophenothiazin-10-yl)propyl]-, trihydrochloride; 2-(4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol; 2-Chloro-10-(3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine; 2-Chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine; 2-Chloro-10-3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl phenothiazine; 2-Chloro-10-3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl phenothiazine; 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine; 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol;2-{4-[3-(2-Chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol; 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol; 4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol; 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Approved [1]
Mixed anxiety and depressive disorder N.A. Investigative [2]
Therapeutic Class
Antipsychotic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 404
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Bioavailability
The bioavailability of drug is 40% []
Clearance
The drug present in the plasma can be removed from the body at the rate of 27 mL/min/kg [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 8 - 12 hours [3]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.99015 micromolar/kg/day [4]
Unbound Fraction
The unbound fraction of drug in plasma is 0.07% [3]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 18 L/kg [3]
Chemical Identifiers
Formula
C21H26ClN3OS
IUPAC Name
2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
Canonical SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO
InChI
InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChIKey
RGCVKNLCSQQDEP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4748
ChEBI ID
CHEBI:8028
CAS Number
58-39-9
DrugBank ID
DB00850
TTD ID
D02HED
VARIDT ID
DR00759
INTEDE ID
DR1264
ACDINA ID
D00521
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [6]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [8]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [10]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [8]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [11]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [12]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Gene/Protein Processing [13]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Schizophrenia
ICD Disease Classification 6A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
P-glycoprotein 1 (ABCB1) DTP P-GP 9.39E-02 1.07E-01 2.80E-01
Organic cation transporter 1 (SLC22A1) DTP SLC22A1 8.54E-01 1.24E-02 7.20E-02
Cytochrome P450 2C18 (CYP2C18) DME CYP2C18 5.67E-02 2.96E-03 1.50E-02
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 1.82E-04 -1.35E-01 -5.84E-01
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 7.36E-01 1.62E-02 1.08E-01
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 2.40E-01 -3.31E-02 -1.97E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 7.30E-01 -1.91E-02 -1.41E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 1.90E-01 -9.81E-03 -5.96E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Perphenazine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Mesoridazine DM2ZGAN Major Increased risk of prolong QT interval by the combination of Perphenazine and Mesoridazine. Schizophrenia [6A20] [14]
Aripiprazole DM3NUMH Moderate Additive anticholinergic effects by the combination of Perphenazine and Aripiprazole. Schizophrenia [6A20] [15]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Perphenazine and Iloperidone. Schizophrenia [6A20] [14]
Paliperidone DM7NPJS Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Paliperidone. Schizophrenia [6A20] [14]
Molindone DMAH70G Moderate Additive anticholinergic effects by the combination of Perphenazine and Molindone. Schizophrenia [6A20] [15]
Thiothixene DMDINC4 Moderate Additive anticholinergic effects by the combination of Perphenazine and Thiothixene. Schizophrenia [6A20] [15]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Perphenazine and Amisulpride. Schizophrenia [6A20] [16]
Asenapine DMSQZE2 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Asenapine. Schizophrenia [6A20] [14]
Pimozide DMW83TP Major Increased risk of prolong QT interval by the combination of Perphenazine and Pimozide. Schizophrenia [6A20] [17]
⏷ Show the Full List of 9 DDI Information of This Drug
Coadministration of a Drug Treating the Disease Different from Perphenazine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Perphenazine and Ivosidenib. Acute myeloid leukaemia [2A60] [18]
Midostaurin DMI6E0R Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Midostaurin. Acute myeloid leukaemia [2A60] [14]
Idarubicin DMM0XGL Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Idarubicin. Acute myeloid leukaemia [2A60] [14]
Arn-509 DMT81LZ Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Arn-509. Acute myeloid leukaemia [2A60] [17]
Oliceridine DM6MDCF Major Additive CNS depression effects by the combination of Perphenazine and Oliceridine. Acute pain [MG31] [19]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Perphenazine and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [20]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Perphenazine and Memantine. Alzheimer disease [8A20] [15]
Rivastigmine DMG629M Moderate Antagonize the effect of Perphenazine when combined with Rivastigmine. Alzheimer disease [8A20] [21]
Metronidazole DMTIVEN Minor Increased risk of prolong QT interval by the combination of Perphenazine and Metronidazole. Amoebiasis [1A36] [22]
Isosorbide dinitrate DMBI4JG Moderate Additive hypotensive effects by the combination of Perphenazine and Isosorbide dinitrate. Anal fissure/fistula [DB50] [23]
Trimethaphan DMHF4IQ Moderate Additive hypotensive effects by the combination of Perphenazine and Trimethaphan. Aneurysm/dissection [BD50] [24]
Bepridil DM0RKS4 Major Increased risk of prolong QT interval by the combination of Perphenazine and Bepridil. Angina pectoris [BA40] [14]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Perphenazine and Dronedarone. Angina pectoris [BA40] [14]
Amyl nitrite DMJKO05 Moderate Additive hypotensive effects by the combination of Perphenazine and Amyl nitrite. Angina pectoris [BA40] [23]
Nifedipine DMSVOZT Moderate Additive hypotensive effects by the combination of Perphenazine and Nifedipine. Angina pectoris [BA40] [23]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Perphenazine and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [25]
Cilostazol DMZMSCT Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Cilostazol. Arterial occlusive disease [BD40] [14]
Posaconazole DMUL5EW Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Posaconazole. Aspergillosis [1F20] [14]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Levalbuterol. Asthma [CA23] [26]
Terbutaline DMD4381 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Terbutaline. Asthma [CA23] [27]
Pirbuterol DMI5678 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Pirbuterol. Asthma [CA23] [27]
Salbutamol DMN9CWF Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Salbutamol. Asthma [CA23] [26]
Formoterol DMSOURV Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Formoterol. Asthma [CA23] [27]
Lisdexamfetamine DM6W8V5 Moderate Antagonize the effect of Perphenazine when combined with Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [28]
Clarithromycin DM4M1SG Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Clarithromycin. Bacterial infection [1A00-1C4Z] [14]
Sulfamethoxazole DMB08GE Minor Increased risk of prolong QT interval by the combination of Perphenazine and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [14]
Sparfloxacin DMB4HCT Major Increased risk of prolong QT interval by the combination of Perphenazine and Sparfloxacin. Bacterial infection [1A00-1C4Z] [29]
Gemifloxacin DMHT34O Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Gemifloxacin. Bacterial infection [1A00-1C4Z] [29]
Norfloxacin DMIZ6W2 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Norfloxacin. Bacterial infection [1A00-1C4Z] [29]
Levofloxacin DMS60RB Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Levofloxacin. Bacterial infection [1A00-1C4Z] [29]
Lomefloxacin DMVRH9C Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Lomefloxacin. Bacterial infection [1A00-1C4Z] [14]
Telithromycin DMZ4P3A Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Telithromycin. Bacterial infection [1A00-1C4Z] [14]
Retigabine DMGNYIH Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Retigabine. Behcet disease [4A62] [14]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Perphenazine and Cariprazine. Bipolar disorder [6A60] [15]
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Eribulin. Breast cancer [2C60-2C6Y] [14]
Lapatinib DM3BH1Y Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Lapatinib. Breast cancer [2C60-2C6Y] [14]
Acetylcholine DMDF79Z Moderate Antagonize the effect of Perphenazine when combined with Acetylcholine. Cataract [9B10] [30]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Perphenazine and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [31]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Olodaterol. Chronic obstructive pulmonary disease [CA22] [27]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Vilanterol. Chronic obstructive pulmonary disease [CA22] [26]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Perphenazine and Tiotropium. Chronic obstructive pulmonary disease [CA22] [31]
Salmeterol DMIEU69 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Salmeterol. Chronic obstructive pulmonary disease [CA22] [27]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Perphenazine and Revefenacin. Chronic obstructive pulmonary disease [CA22] [31]
Indacaterol DMQJHR7 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Indacaterol. Chronic obstructive pulmonary disease [CA22] [27]
Arformoterol DMYM974 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Arformoterol. Chronic obstructive pulmonary disease [CA22] [27]
Dihydrocodeine DMB0FWL Major Additive CNS depression effects by the combination of Perphenazine and Dihydrocodeine. Chronic pain [MG30] [32]
Isoproterenol DMK7MEY Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Isoproterenol. Conduction disorder [BC63] [26]
Sevoflurane DMC9O43 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Sevoflurane. Corneal disease [9A76-9A78] [14]
Remifentanil DMZTXCH Major Additive CNS depression effects by the combination of Perphenazine and Remifentanil. Corneal disease [9A76-9A78] [19]
Probucol DMVZQ2M Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Probucol. Coronary atherosclerosis [BA80] [14]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Perphenazine and Pasireotide. Cushing syndrome [5A70] [14]
Cyclandelate DMO0R76 Moderate Additive hypotensive effects by the combination of Perphenazine and Cyclandelate. Dementia [6D80-6D8Z] [23]
Selegiline DM6034S Moderate Additive hypotensive effects by the combination of Perphenazine and Selegiline. Depression [6A70-6A7Z] [33]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Perphenazine and Isocarboxazid. Depression [6A70-6A7Z] [33]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Perphenazine and Escitalopram. Depression [6A70-6A7Z] [14]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Perphenazine and OPC-34712. Depression [6A70-6A7Z] [15]
Clomipramine DMINRKW Moderate Increased plasma concentrations of Perphenazine and Clomipramine due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [34]
Doxepin DMPI98T Moderate Increased plasma concentrations of Perphenazine and Doxepin due to competitive inhibition of the same metabolic pathway. Depression [6A70-6A7Z] [35]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Perphenazine and Maprotiline. Depression [6A70-6A7Z] [15]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Perphenazine and Esketamine. Depression [6A70-6A7Z] [22]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Perphenazine and Mepenzolate. Digestive system disease [DE2Z] [15]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Perphenazine and Oxybutynine. Discovery agent [N.A.] [15]
Tetrabenazine DMYWQ0O Major Additive antidopaminergic effects by the combination of Perphenazine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [36]
Deutetrabenazine DMUPFLI Major Increased risk of prolong QT interval by the combination of Perphenazine and Deutetrabenazine. Dystonic disorder [8A02] [37]
Zonisamide DM0DTF7 Major Increased risk of hyperpyrexia by the combination of Perphenazine and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [38]
Diphenhydramine DMKQTBA Moderate Antagonize the effect of Perphenazine when combined with Diphenhydramine. Episodic vestibular syndrome [AB31] [39]
Ethacrynic acid DM60QMR Moderate Additive hypotensive effects by the combination of Perphenazine and Ethacrynic acid. Essential hypertension [BA00] [24]
Phenoxybenzamine DM8KSQH Moderate Additive hypotensive effects by the combination of Perphenazine and Phenoxybenzamine. Essential hypertension [BA00] [23]
Nadolol DMW6GVL Moderate Additive hypotensive effects by the combination of Perphenazine and Nadolol. Essential hypertension [BA00] [23]
Solifenacin DMG592Q Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Solifenacin. Functional bladder disorder [GC50] [14]
Mirabegron DMS1GYT Moderate Decreased metabolism of Perphenazine caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [40]
Tolterodine DMSHPW8 Moderate Additive anticholinergic effects by the combination of Perphenazine and Tolterodine. Functional bladder disorder [GC50] [15]
Terbinafine DMI6HUW Moderate Decreased metabolism of Perphenazine caused by Terbinafine mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [41]
Ketoconazole DMPZI3Q Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Ketoconazole. Fungal infection [1F29-1F2F] [14]
Sunitinib DMCBJSR Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Sunitinib. Gastrointestinal stromal tumour [2B5B] [14]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Perphenazine when combined with Pilocarpine. Glaucoma [9C61] [30]
Carvedilol DMHTEAO Moderate Additive hypotensive effects by the combination of Perphenazine and Carvedilol. Heart failure [BD10-BD1Z] [23]
Chlorothiazide DMLHESP Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Chlorothiazide. Heart failure [BD10-BD1Z] [22]
Bumetanide DMRV7H0 Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Bumetanide. Heart failure [BD10-BD1Z] [22]
Procarbazine DMIK367 Moderate Additive CNS depression effects by the combination of Perphenazine and Procarbazine. Hodgkin lymphoma [2B30] [33]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Perphenazine caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [42]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Perphenazine and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [43]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [14]
Isosorbide mononitrate DMYLMU0 Moderate Additive hypotensive effects by the combination of Perphenazine and Isosorbide mononitrate. Hydrocephalus [8D64] [23]
Cinacalcet DMCX0K3 Moderate Decreased metabolism of Perphenazine caused by Cinacalcet mediated inhibition of CYP450 enzyme. Hyper-parathyroidism [5A51] [22]
Eprosartan DM07K2I Moderate Additive hypotensive effects by the combination of Perphenazine and Eprosartan. Hypertension [BA00-BA04] [23]
Acebutolol DM0TI4U Moderate Additive hypotensive effects by the combination of Perphenazine and Acebutolol. Hypertension [BA00-BA04] [23]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Perphenazine and Captopril. Hypertension [BA00-BA04] [23]
Penbutolol DM4ES8F Moderate Additive hypotensive effects by the combination of Perphenazine and Penbutolol. Hypertension [BA00-BA04] [23]
Methyldopa DM5I621 Moderate Additive hypotensive effects by the combination of Perphenazine and Methyldopa. Hypertension [BA00-BA04] [23]
Nebivolol DM7F1PA Moderate Additive hypotensive effects by the combination of Perphenazine and Nebivolol. Hypertension [BA00-BA04] [23]
Levamlodipine DM92S6N Moderate Additive hypotensive effects by the combination of Perphenazine and Levamlodipine. Hypertension [BA00-BA04] [23]
TAK-491 DMCF6SX Moderate Additive hypotensive effects by the combination of Perphenazine and TAK-491. Hypertension [BA00-BA04] [23]
Trichlormethiazide DMHAQCO Moderate Additive hypotensive effects by the combination of Perphenazine and Trichlormethiazide. Hypertension [BA00-BA04] [23]
Diazoxide DML1538 Moderate Additive hypotensive effects by the combination of Perphenazine and Diazoxide. Hypertension [BA00-BA04] [23]
Felodipine DMOSW35 Moderate Additive hypotensive effects by the combination of Perphenazine and Felodipine. Hypertension [BA00-BA04] [23]
Quinapril DMR8H31 Moderate Additive hypotensive effects by the combination of Perphenazine and Quinapril. Hypertension [BA00-BA04] [23]
Deserpidine DMRH7CV Moderate Additive hypotensive effects by the combination of Perphenazine and Deserpidine. Hypertension [BA00-BA04] [23]
Telmisartan DMS3GX2 Moderate Additive hypotensive effects by the combination of Perphenazine and Telmisartan. Hypertension [BA00-BA04] [23]
Irbesartan DMTP1DC Moderate Additive hypotensive effects by the combination of Perphenazine and Irbesartan. Hypertension [BA00-BA04] [23]
Clevidipine butyrate DMW4M97 Moderate Additive hypotensive effects by the combination of Perphenazine and Clevidipine butyrate. Hypertension [BA00-BA04] [23]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Perphenazine and Belladonna. Infectious gastroenteritis/colitis [1A40] [15]
Amantadine DMS3YE9 Moderate Additive anticholinergic effects by the combination of Perphenazine and Amantadine. Influenza [1E30-1E32] [44]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Perphenazine caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [45]
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Perphenazine and ITI-007. Insomnia [7A00-7A0Z] [15]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Perphenazine and Polyethylene glycol. Irritable bowel syndrome [DD91] [14]
Phenolphthalein DM5SICT Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Phenolphthalein. Irritable bowel syndrome [DD91] [14]
Physostigmine DM2N0TO Moderate Antagonize the effect of Perphenazine when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [21]
Glycerol phenylbutyrate DMDGRQO Moderate Decreased metabolism of Perphenazine caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme. Liver disease [DB90-DB9Z] [17]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Perphenazine and Crizotinib. Lung cancer [2C25] [46]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Perphenazine and Ceritinib. Lung cancer [2C25] [14]
Dacomitinib DMOH8VY Moderate Decreased metabolism of Perphenazine caused by Dacomitinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [47]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Perphenazine and Osimertinib. Lung cancer [2C25] [48]
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Perphenazine and Lumefantrine. Malaria [1F40-1F45] [22]
Halofantrine DMOMK1V Major Increased risk of prolong QT interval by the combination of Perphenazine and Halofantrine. Malaria [1F40-1F45] [49]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Perphenazine and Hydroxychloroquine. Malaria [1F40-1F45] [50]
Primaquine DMWQ16I Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Primaquine. Malaria [1F40-1F45] [14]
Inotuzumab ozogamicin DMAC130 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [17]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Perphenazine and Arsenic trioxide. Mature B-cell lymphoma [2A85] [51]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Perphenazine and Vemurafenib. Melanoma [2C30] [14]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and LGX818. Melanoma [2C30] [52]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Perphenazine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [53]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Perphenazine and Lasmiditan. Migraine [8A80] [54]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Perphenazine and Flibanserin. Mood disorder [6A60-6E23] [55]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Perphenazine and Thalidomide. Multiple myeloma [2A83] [56]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Perphenazine and Siponimod. Multiple sclerosis [8A40] [22]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Perphenazine and Fingolimod. Multiple sclerosis [8A40] [14]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Perphenazine and Ozanimod. Multiple sclerosis [8A40] [57]
Romidepsin DMT5GNL Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Romidepsin. Mycosis fungoides [2B01] [14]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Perphenazine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [17]
Nilotinib DM7HXWT Major Increased risk of prolong QT interval by the combination of Perphenazine and Nilotinib. Myeloproliferative neoplasm [2A20] [14]
Dasatinib DMJV2EK Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Dasatinib. Myeloproliferative neoplasm [2A20] [58]
Dextroamphetamine DMMIHVP Moderate Antagonize the effect of Perphenazine when combined with Dextroamphetamine. Narcolepsy [7A20] [28]
Phenindamine DMDTC7R Moderate Additive anticholinergic effects by the combination of Perphenazine and Phenindamine. Nasopharyngitis [CA00] [15]
Dimenhydrinate DM264B3 Moderate Additive anticholinergic effects by the combination of Perphenazine and Dimenhydrinate. Nausea/vomiting [MD90] [15]
Promethazine DM6I5GR Moderate Additive anticholinergic effects by the combination of Perphenazine and Promethazine. Nausea/vomiting [MD90] [15]
Rolapitant DM8XP26 Moderate Decreased metabolism of Perphenazine caused by Rolapitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [59]
Cyclizine DM9G7BS Moderate Additive anticholinergic effects by the combination of Perphenazine and Cyclizine. Nausea/vomiting [MD90] [15]
Metoclopramide DMFA5MY Major Additive antidopaminergic effects by the combination of Perphenazine and Metoclopramide. Nausea/vomiting [MD90] [60]
Granisetron DMIUW25 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Granisetron. Nausea/vomiting [MD90] [14]
Ondansetron DMOTQ1I Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Ondansetron. Nausea/vomiting [MD90] [14]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Perphenazine and Bupropion. Nicotine use disorder [6C4A] [14]
Phendimetrazine DM6TS1N Moderate Antagonize the effect of Perphenazine when combined with Phendimetrazine. Obesity [5B80-5B81] [28]
Amfepramone DM9YSNQ Moderate Antagonize the effect of Perphenazine when combined with Amfepramone. Obesity [5B80-5B81] [28]
Lorcaserin DMG6OYJ Moderate Increased risk of hyperprolactinemic effects by the combination of Perphenazine and Lorcaserin. Obesity [5B80-5B81] [61]
Benzphetamine DMIJATC Moderate Antagonize the effect of Perphenazine when combined with Benzphetamine. Obesity [5B80-5B81] [28]
Polythiazide DMCH80F Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Polythiazide. Oedema [MG29] [22]
Levomethadyl Acetate DM06HG5 Major Increased risk of prolong QT interval by the combination of Perphenazine and Levomethadyl Acetate. Opioid use disorder [6C43] [17]
Lofexidine DM1WXA6 Moderate Additive hypotensive effects by the combination of Perphenazine and Lofexidine. Opioid use disorder [6C43] [14]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Perphenazine and Apraclonidine. Optic nerve disorder [9C40] [62]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Rucaparib. Ovarian cancer [2C73] [14]
Oxymorphone DM65AGJ Major Additive CNS depression effects by the combination of Perphenazine and Oxymorphone. Pain [MG30-MG3Z] [19]
Levorphanol DMGS80V Major Additive CNS depression effects by the combination of Perphenazine and Levorphanol. Pain [MG30-MG3Z] [19]
Dezocine DMJDB0Y Major Additive CNS depression effects by the combination of Perphenazine and Dezocine. Pain [MG30-MG3Z] [19]
Buprenorphine DMPRI8G Major Additive CNS depression effects by the combination of Perphenazine and Buprenorphine. Pain [MG30-MG3Z] [63]
Hydrocodone DMQ2JO5 Major Additive CNS depression effects by the combination of Perphenazine and Hydrocodone. Pain [MG30-MG3Z] [19]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Triclabendazole. Parasitic worm infestation [1F90] [14]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Perphenazine and Safinamide. Parkinsonism [8A00] [33]
Pergolide DM14MAE Moderate Antagonize the effect of Perphenazine when combined with Pergolide. Parkinsonism [8A00] [64]
Opicapone DM1BKA6 Moderate Antagonize the effect of Perphenazine when combined with Opicapone. Parkinsonism [8A00] [64]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Perphenazine and Rasagiline. Parkinsonism [8A00] [33]
Levodopa DMN3E57 Moderate Antagonize the effect of Perphenazine when combined with Levodopa. Parkinsonism [8A00] [64]
Pimavanserin DMR7IVC Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Pimavanserin. Parkinsonism [8A00] [65]
Bromocriptine DMVE3TK Moderate Antagonize the effect of Perphenazine when combined with Bromocriptine. Parkinsonism [8A00] [64]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Perphenazine and Methylscopolamine. Peptic ulcer [DA61] [15]
Famotidine DMRL3AB Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Famotidine. Peptic ulcer [DA61] [22]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Perphenazine and Macimorelin. Pituitary gland disorder [5A60-5A61] [66]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Perphenazine and Lefamulin. Pneumonia [CA40] [67]
Ritodrine DM4V6RL Moderate Increased risk of ventricular arrhythmias by the combination of Perphenazine and Ritodrine. Preterm labour/delivery [JB00] [27]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Degarelix. Prostate cancer [2C82] [17]
Enzalutamide DMGL19D Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Enzalutamide. Prostate cancer [2C82] [17]
Bicalutamide DMZMSPF Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Bicalutamide. Prostate cancer [2C82] [17]
Terazosin DM3JCVS Moderate Additive hypotensive effects by the combination of Perphenazine and Terazosin. Prostate hyperplasia [GA90] [23]
Silodosin DMJSBT6 Moderate Additive hypotensive effects by the combination of Perphenazine and Silodosin. Prostate hyperplasia [GA90] [23]
Levomepromazine DMIKFEL Moderate Additive anticholinergic effects by the combination of Perphenazine and Levomepromazine. Psychotic disorder [6A20-6A25] [15]
Gatifloxacin DMSL679 Major Increased risk of prolong QT interval by the combination of Perphenazine and Gatifloxacin. Respiratory infection [CA07-CA4Z] [68]
Neupro DMHEAB1 Moderate Additive hypotensive effects by the combination of Perphenazine and Neupro. Restless legs syndrome [7A80] [64]
Vardenafil DMTBGW8 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Vardenafil. Sexual dysfunction [HA00-HA01] [14]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Perphenazine and LEE011. Solid tumour/cancer [2A00-2F9Z] [14]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Perphenazine and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [14]
Triptorelin DMTK4LS Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [17]
Doxorubicin DMVP5YE Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [14]
Pitolisant DM8RFNJ Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Pitolisant. Somnolence [MG42] [14]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Lenvatinib. Thyroid cancer [2D10] [14]
Papaverine DMCA9QP Moderate Additive hypotensive effects by the combination of Perphenazine and Papaverine. Tonus and reflex abnormality [MB47] [23]
Tacrolimus DMZ7XNQ Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Tacrolimus. Transplant rejection [NE84] [14]
Methdilazine DMAUHQX Moderate Additive anticholinergic effects by the combination of Perphenazine and Methdilazine. Vasomotor/allergic rhinitis [CA08] [15]
Trimeprazine DMEMV9D Moderate Additive anticholinergic effects by the combination of Perphenazine and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [20]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Perphenazine and Acrivastine. Vasomotor/allergic rhinitis [CA08] [15]
Procainamide DMNMXR8 Major Increased risk of prolong QT interval by the combination of Perphenazine and Procainamide. Ventricular tachyarrhythmia [BC71] [14]
Propafenone DMPIBJK Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Propafenone. Ventricular tachyarrhythmia [BC71] [14]
Flecainide DMSQDLE Moderate Increased risk of prolong QT interval by the combination of Perphenazine and Flecainide. Ventricular tachyarrhythmia [BC71] [14]
Amiodarone DMUTEX3 Major Increased risk of prolong QT interval by the combination of Perphenazine and Amiodarone. Ventricular tachyarrhythmia [BC71] [14]
⏷ Show the Full List of 193 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Calcium carbonate E00198 10112 Binding agent; Buffering agent; Diluent; Opacifying agent
Isopropyl alcohol E00070 3776 Antimicrobial preservative; Solvent
Sodium benzoate E00432 517055 Antimicrobial preservative; lubricant
Acetone E00004 180 Solvent
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 6000 E00655 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 16 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Perphenazine 2 mg tablet 2 mg Oral Tablet Oral
Perphenazine 8 mg tablet 8 mg Oral Tablet Oral
Perphenazine 16 mg tablet 16 mg Oral Tablet Oral
Perphenazine 4 mg tablet 4 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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