Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA30RW)

Drug Name

(S,R)-(+)-fenoterol Drug Info

Synonyms

(S,R)-(+)-fenoterol; CHEMBL229477; (S,R)-Fenoterol; AC1LDIMM; SCHEMBL9971023; ZINC20252; BDBM50213103; 5-[(1S)-1-hydroxy-2-[[(2R)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 667688
TTD Drug ID: DMA30RW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Adrenergic receptor beta-2 (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indacaterol	DMQJHR7	Chronic obstructive pulmonary disease	CA22	Approved	[2]
Formoterol	DMSOURV	Allergic asthma	CA23.0	Approved	[3]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[4]
Arformoterol	DMYM974	Chronic obstructive pulmonary disease	CA22	Approved	[5]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[6]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[7]
Clenbuterol	DMCKYZ5	Chronic breathing disorder	7A4Z	Approved	[8]
Ritodrine	DM4V6RL	Premature labour	JB00	Approved	[9]
Olodaterol	DM62B78	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Inhibitor	[1]

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References

1	Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007 Jun 14;50(12):2903-15.
2	Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94.
3	Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversible airflow limitation. Cochrane Database Syst Rev. 2002;(3):CD001104.
4	Potential of beta2-adrenoceptor agonists as add-on therapy for multiple sclerosis: focus on salbutamol (albuterol). CNS Drugs. 2002;16(1):1-8.
5	Arformoterol tartrate in the treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease. Drugs Today (Barc). 2009 Jan;45(1):3-9.
6	Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.
7	Pharmacogenetic tests in asthma therapy. Clin Lab Med. 2008 Dec;28(4):645-65.
8	Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg. 2009 Jan;108(1):280-7.
9	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
11	Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. J Cell Physiol. 2009 Jul;220(1):267-75.