Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA4L5P)

• Drug Name: N-[4-(4-Phenyl-piperazin-1-yl)-butyl]-benzamide Drug Info
• Synonyms: CHEMBL27393; N-[4-(4-Phenyl-piperazin-1-yl)-butyl]-benzamide; BDBM50022717

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 14162480
  TTD Drug ID: DMA4L5P

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[2]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[3]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[4]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[5]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[6]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[7]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[8]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[9]
Treximet	DMU54QB	Migraine	8A80	Approved	[10]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]

References

• [1] Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. J Med Chem. 1988 Oct;31(10):1968-71.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [3] Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.
• [4] Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
• [5] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
• [6] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [7] Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
• [8] Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993).
• [9] Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
• [10] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)