Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAZ28C)

Drug Name

Metazosin Drug Info

Synonyms

Metazosin; Kenosin; VUFB15111; 116728-65-5; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-methoxy-1-oxopropyl)piperazine; (+-)-4-Amino-2-(4-(2-methoxypropionyl)piperazino)-6,7-dimethoxyquinazoline; (+-)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-methoxypropionyl)piperazine; 95549-92-1; 1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-methoxypropan-1-one; Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-methoxy-1-oxopropyl)-

Indication

Disease Entry	ICD 11	Status	REF
Cardiac disease	BA00-BE2Z	Discontinued in Phase 3	[1]

Cross-matching ID

PubChem CID: 93514
CAS Number: CAS 95549-92-1
TTD Drug ID: DMAZ28C

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Adrenergic receptor Alpha-1 (ADRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[3]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[3]
Prazosin	DMCD9YG	Benign prostatic hyperplasia	GA90	Approved	[4]
Ergotamine	DMKR3C5	Cluster headache	8A81.0	Approved	[5]
Midodrine	DME2PY5	Orthostatic hypotension	BA21	Approved	[6]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[7]
Phenylpropanolamine	DMTFK3O	Allergic rhinitis	CA08.0	Withdrawn from market	[8]
DC-015	DMCDMWJ	N. A.	N. A.	Terminated	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor Alpha-1 (ADRA1)	TTG28O6	NOUNIPROTAC	Antagonist	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002056)
2	Metazosin tablets (Kenosin) in the treatment of chronic congestive heart failure. Cas Lek Cesk. 1995 Sep 20;134(18):590-3.
3	Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
4	Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Auton Autacoid Pharmacol. 2009 Jul;29(3):117-33.
5	Reversal of ergotamine-induced vasospasm following methylprednisolone. Clin Toxicol (Phila). 2008 Dec;46(10):1074-6.
6	Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505.
7	Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
8	Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35.
9	Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats. J Biomed Sci. 1996 Apr;3(2):108-116.