Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB9CQL)

Drug Name

(S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine Drug Info

Synonyms

UNII-XY1C8J4WGF; XY1C8J4WGF; CHEMBL308538; 186588-98-7; F-A-85380; CHEMBL449437; F-A 85380 Tartrate; (S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine; 2-Fluoro-A 85380; 2-Fluoro-A-85380; A-85380, 2-fluoro; 2-Fluoro-3-(((2S)-2-azetidinyl)methoxy)pyridine; Pyridine, 3-[(2S)-2-azetidinylmethoxy]-2-fluoro-; SCHEMBL1220341; ZINC6525315; FCH858175; BDBM50066788; BDBM50263094; AKOS006285963; ACM209530938; J1.007.103H; 2-fluoro-3-(2(s)-azetidinylmethoxy)pyridine; 3-((S)-1-Azetidin-2-ylmethoxy)-2-fluoro-pyridine; Pyridine, 3-((2S)-2-azetidin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10241442
CAS Number: CAS 186588-98-7
TTD Drug ID: DMB9CQL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[2]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[2]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[2]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[2]
Levallorphan	DMCOLUP	Narcotic depression	6A7Z	Approved	[3]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[2]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[3]
Pipecuronium	DM5F84A	Spasm	MB47.3	Approved	[3]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[4]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Inhibitor	[1]

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References

1	Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acety... Bioorg Med Chem. 2009 Jul 1;17(13):4367-77.
2	Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
3	Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
4	Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6.
5	Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8.