Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBZMYT)

• Drug Name: Pyridine derivative 18 Drug Info
• Synonyms: PMID27646564-Compound-5
• Cross-matching ID: TTD Drug ID: DMBZMYT

Molecule-Related Drug Atlas

Drug(s) Targeting Macrophage colony-stimulating factor 1 receptor (CSF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[2]
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[3]
ARRY-382	DM0VGDC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
BLZ-945	DMG1LVA	Amyotrophic lateral sclerosis	8B60.0	Phase 2	[3]
Cabiralizumab	DMGE058	Pancreatic cancer	2C10	Phase 2	[4]
AMB-05X	DM958C5	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[5]
FPA-008	DM3ZN6Y	Autoimmune diabetes	5A10	Phase 1/2	[6]
DCC-3014	DMHW289	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[3]
DCC-3014	DMHW289	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[7]
PLX7486	DM0IVGU	Pancreatic cancer	2C10	Phase 1	[3]

Drug(s) Targeting Platelet-derived growth factor receptor alpha (PDGFRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[8]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[9]
Olaratumab	DMNYOIX	Soft tissue sarcoma	2B57	Approved	[10]
Avapritinib	DMK2GZX	Gastrointestinal stromal tumour	2B5B	Approved	[11]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[12]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[13]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]
MP470	DMELUAK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
MEDI-575	DMI9WVM	Glioblastoma multiforme	2A00.0	Phase 2	[17]

Drug(s) Targeting Tyrosine-protein kinase Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[19]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[20]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[21]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[22]
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[2]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[9]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]

Drug(s) Targeting Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[19]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[8]
Becaplermin	DM1R5X4	Diabetic complication	5A2Y	Approved	[23]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[12]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[24]
SNN-0031	DM2X3BR	Brain injury	NA07.Z	Phase 1/2	[25]
TAK-593	DMNFZOT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[26]
PMID25656651-Compound-21a	DMCKAON	N. A.	N. A.	Patented	[27]

Drug(s) Targeting Proto-oncogene c-Ret (RET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[28]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[21]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[18]
Selpercatinib	DMZR15V	Non-small-cell lung cancer	2C25.Y	Approved	[29]
Pralsetinib	DMWU0I2	Non-small-cell lung cancer	2C25.Y	Approved	[30]
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[31]
CEP-32496	DMAO04B	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[3]
TPX-0046	DMIVE67	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[32]
GSK3179106	DM2KCIP	Inflammatory bowel disease	DD72	Phase 1	[33]

Drug(s) Targeting Fms-like tyrosine kinase 3 (FLT-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[35]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[18]
Gilteritinib	DMTI0ZO	Acute myeloid leukaemia	2A60	Approved	[36]
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[2]
Pacritinib	DM1T6ZN	Myelofibrosis	2A20.2	Approved	[34]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[3]
Lestaurtinib	DMQ2AIJ	Acute myeloid leukaemia	2A60	Approved (orphan drug)	[37]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[14]

Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[19]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[38]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[21]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[39]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[40]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[18]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[22]
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[41]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[42]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[43]

Drug(s) Targeting Proto-oncogene c-Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[18]
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[18]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[44]
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[45]
AL3818	DM3WP0N	Alveolar soft part sarcoma	2A60-2C35	Phase 3	[3]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[3]
Masitinib	DMRSNEU	Amyotrophic lateral sclerosis	8B60.0	Phase 3	[33]
KX-01	DMF0NA9	Actinic keratosis	EK90.0	Phase 3	[46]
Saracatinib	DMBLHGP	Hematologic tumour	2B33.Y	Phase 2	[47]
TPX-0046	DMIVE67	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[32]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fms-like tyrosine kinase 3 (FLT-3)	TTGJCWZ	FLT3_HUMAN	Inhibitor	[1]
Macrophage colony-stimulating factor 1 receptor (CSF1R)	TT7MRDV	CSF1R_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor alpha (PDGFRA)	TT8FYO9	PGFRA_HUMAN	Inhibitor	[1]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[1]
Proto-oncogene c-Ret (RET)	TT4DXQT	RET_HUMAN	Inhibitor	[1]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase Kit (KIT)	TTX41N9	KIT_HUMAN	Inhibitor	[1]
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

References

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