General Information of Drug (ID: DMD0NA1)

Drug Name
TP 6076 Drug Info
Indication
Disease Entry ICD 11 Status REF
Multidrug resistant infection MG51 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMD0NA1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrofurazone DMSM2KE Skin burns ME65.0 Approved [3]
Gentamicin DMKINJO Bacteremia 1A73 Approved [4]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [5]
TP-434 DM5A31S Intra-abdominal infection 1A40 Approved [6]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [4]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [7]
Sarecycline DMLZNIQ Acne vulgaris ED80 Approved [8]
ME1100 DM39PSZ Bacterial pneumonia CA40.0 Phase 1 [9]
TP-6076 DM5RIT8 Enterobacteriaceae infection MG50.C Phase 1 [2]
TP-271 DM3PJSE Pneumonia CA40 Phase 1 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA) TTOVFH2 NOUNIPROTAC Inhibitor [2]

References

1 ClinicalTrials.gov (NCT03691584) Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers (BAL). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.
3 The antibiotic Furvina targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Mechanism of action of aminoglycoside antibiotics.Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits.Eur J Biochem.1979 Dec;102(1):73-81.
6 The antibiotic arms race: current and emerging therapy for Klebsiella pneumoniae carbapenemase (KPC) - producing bacteria.Expert Opin Pharmacother. 2018 Oct 22:1-13.
7 Omadacycline Enters the Ring: A New Antimicrobial Contender.Pharmacotherapy. 2018 Dec;38(12):1194-1204.
8 Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01297-18.
9 ClinicalTrials.gov (NCT01961830) Intrapulmonary Pharmacokinetics of ME1100 in Healthy Volunteers. U.S. National Institutes of Health.
10 Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.