Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME5WZQ)

Drug Name
7-methoxy-2-p-tolyl-4H-chromen-4-one Drug Info
Synonyms
CHEMBL17052; 7-methoxy-2-(4-methylphenyl)chromen-4-one; 7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one; 108980-49-0; 7-methoxy-2-p-tolyl-4H-chromen-4-one; AC1LIGD7; MolPort-000-450-862; ZINC522064; STK893155; BDBM50310185; 7-Methoxy-2-p-tolyl-chromen-4-one; AKOS002182021; MCULE-3043616847; NCGC00318207-01; 7-methoxy-2-(p-tolyl)-4H-chromen-4-one; ST50070846; VU0510077-1; AB01311569-01; 2-(4-Methylphenyl)-7-methoxy-4H-1-benzopyran-4-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
930709
TTD Drug ID
DME5WZQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Monoamine oxidase type B (MAO-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [2]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [3]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [4]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [5]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [6]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [7]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [8]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [9]
Indeloxazine DMWO3N6 Dementia 6D80-6D86 Approved [10]
Budipine DMODHQI Migraine 8A80 Approved [11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

References

1 A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9.
2 Emerging drugs for Parkinson's disease. Expert Opin Emerg Drugs. 2006 Sep;11(3):403-17.
3 Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors. Pharmacol Res. 2008 Jun;57(6):426-34.
4 Tranylcypromine: new perspectives on an "old" drug. Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):268-73.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).
6 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
7 Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res. 2009 Aug;16(2):148-59.
8 Novel monoamine oxidase inhibitors, 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, and their differential reversibility. Jpn J Pharmacol. 2002 Feb;88(2):174-82.
9 Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H821-8.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
11 Multiple mechanisms of action: the pharmacological profile of budipine. J Neural Transm Suppl. 1999;56:83-105.