Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME9U7Y)

Drug Name

N-Carboxymethyl-N-cyclopentyl-phthalamic acid Drug Info

Synonyms

CHEMBL115153; N-Carboxymethyl-N-cyclopentyl-phthalamic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44340905
TTD Drug ID: DME9U7Y

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[2]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[3]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[4]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[5]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[6]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[7]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[8]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[9]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[10]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[1]

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References

1	Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids. J Med Chem. 1985 Mar;28(3):328-32.
2	Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
3	Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005 Sep;19(11):1474-81.
4	Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.
5	Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83.
6	Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
7	Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
8	Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.
9	Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7.
10	Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8.
11	Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient m... J Atheroscler Thromb. 2009 Jun;16(3):164-71.