Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG0H8K)

• Drug Name: Bictegravir, emtricitabine and tenofovir alafenamide Drug Info
• Synonyms: S900007760; Bictegravir mixture with emtricitabine and tenofovir alafenamide

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Approved	[1]

• Cross-matching ID:
  PubChem CID: 129626368
  TTD Drug ID: DMG0H8K

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[2]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[3]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[4]
Tenofovir	DM1IS6U	Human immunodeficiency virus infection	1C62	Approved	[2]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[5]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[6]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[5]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[5]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[7]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[8]

Drug(s) Targeting Human immunodeficiency virus Integrase (HIV IN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[9]
Raltegravir	DMYURI6	Human immunodeficiency virus infection	1C62	Approved	[10]
Elvitegravir	DMG9B1U	Human immunodeficiency virus infection	1C62	Approved	[9]
GSK1265744	DMT8J0I	Human immunodeficiency virus infection	1C62	Phase 3	[11]
S-1360	DM9KTSG	Human immunodeficiency virus infection	1C62	Phase 2	[12]
S-364735	DMU7ZMH	Human immunodeficiency virus infection	1C62	Phase 2	[13]
C-2507	DMOFT1V	Human immunodeficiency virus infection	1C62	Phase 1	[14]
Acriflavine	DMKVE8X	Human immunodeficiency virus infection	1C62	Phase 1	[15]
S-265744 LAP	DMDQRWT	Human immunodeficiency virus infection	1C62	Phase 1	[16]
JTK-656	DMEADBG	Human immunodeficiency virus infection	1C62	Discontinued in Phase 1	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Integrase (HIV IN)	TT5FH9Y	POL_HV1B1	Inhibitor	[1]
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[1]

References

• [1] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [2] Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33.
• [3] HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.Nat Struct Mol Biol.2012 Jan 22;19(2):253-9.
• [4] A peptide inhibitor of HIV-1 reverse transcriptase using alpha,beta-dehydro residues: a structure-based computer model. J Biomol Struct Dyn. 1998 Oct;16(2):347-54.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [6] Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only Curr HIV Res. 2009 May;7(3):320-6.
• [7] Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416.
• [8] 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
• [9] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [10] 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
• [11] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [12] HIV-1 integrase inhibitors: an emerging clinical reality. Drugs R D. 2007;8(3):155-68.
• [13] The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8.
• [14] Elvitegravir: a new HIV integrase inhibitor. Antivir Chem Chemother. 2009 Oct 19;20(2):79-85.
• [15] Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment. Biomed Pharmacother. 1999 Dec;53(10):484-6.
• [16] Long-acting shot prevents infection with HIV analogue. Nature. doi:10.1038/nature.2014.14819. 04 March 2014
• [17] US patent application no. 8,497,270, Macrocyclic integrase inhibitors.