Details of the Drug-Related molecule(s) Interaction Atlas

Monomethyl-auristatin-E Drug Info

Monomethyl auristatin E; UNII-V7I58RC5EJ; MMAE; V7I58RC5EJ; N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide; Monomethyl auristatin E (MMAE); Monomethylauristatin E; 4Q5; monomethyl-auristatin-e-mmae; MMAE, monomethyl auristatin E; SCHEMBL5402144; CHEMBL2103835; AOB5196; DASWEROEPLKSEI-UIJRFTGLSA-N; C39H67N5O7; MFCD22124498; ZINC85537145; s7721; CS-0837

Cross-matching ID

PubChem CID

11542188

CAS Number

CAS 474645-27-7

TTD Drug ID

DMG2UJS

VARIDT Drug ID

DR01708

General Information of Drug (ID: DMG2UJS)

Molecule-Related Drug Atlas

Molecule Type:

DTP

Drug Status:

Approved Drug(s)

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Drug(s) Transported By Multidrug resistance-associated protein 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[3]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[4]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[5]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[6]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[7]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[8]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[9]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[1]

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References

1	Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res. 2008 Jul 1;68(13):5380-9.
2	Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
3	Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
4	ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
5	Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30.
6	Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702.
7	Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102.
8	Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73.
9	Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21.
10	Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7.
11	Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.