Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHY30B)

• Drug Name: Diphosphate Drug Info
• Synonyms: Pyrophosphate ion; 14000-31-8; UNII-X3SSV2V6L3; Diphosphate(4-); X3SSV2V6L3; phosphonato phosphate; diphospate; Pyrophosphat; Diphosphat; Pyrophosphate(4-); 2o1c; mu-oxo-hexaoxodiphosphate; AC1LD8JZ; Phosphate (P2O74-); Diphosphate (P2O74-); Pyrophosphate (P2O74-); Diphosphoric acid tetraanion; diphosphoric acid, ion(4-); DTXSID4074514; CHEBI:18361; CTK0H7511; 3c14; XPPKVPWEQAFLFU-UHFFFAOYSA-J; [O3POPO3](4-); mu-oxido-bis(trioxidophosphate)(4-); BDBM50278316; P2O7(4-)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 644102
  ChEBI ID: CHEBI:18361
  CAS Number: CAS 14000-31-8
  TTD Drug ID: DMHY30B

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[2]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Plasmodium Adenylosuccinate synthetase (Malaria Adss)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[1]
Guanosine-5'-Diphosphate	DM0MUKQ	Discovery agent	N.A.	Investigative	[1]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[1]
6-Cl-IMP	DMNTDFV	Discovery agent	N.A.	Investigative	[3]
(Carboxyhydroxyamino)Ethanoic Acid	DMZB0C3	Discovery agent	N.A.	Investigative	[1]
(C8-R)-Hydantocidin 5'-Phosphate	DM5WH6R	Discovery agent	N.A.	Investigative	[1]
(C8-S)-Hydantocidin 5'-Phosphate	DMMH179	Discovery agent	N.A.	Investigative	[1]
6-O-Phosphoryl Inosine Monophosphate	DM6YHBR	Discovery agent	N.A.	Investigative	[1]
Hydantocidin-5'-Monophosphate	DMOTXP1	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[2]
2'-deoxythymidine triphosphate	DM9OEJT	Discovery agent	N.A.	Investigative	[1]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[1]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[1]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate	DMM4VWD	Discovery agent	N.A.	Investigative	[4]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate	DMU08MN	Discovery agent	N.A.	Investigative	[1]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate	DMWVCJ1	Discovery agent	N.A.	Investigative	[1]
CHLORODEOXYURIDINE	DMQT3WJ	Discovery agent	N.A.	Investigative	[5]
BROMODEOXYURIDINE	DM0D7LA	Discovery agent	N.A.	Investigative	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)	TT8WCXO	NADE_ECOLI	Inhibitor	[1]
Mycobacterium Thymidine monophosphate kinase (MycB tmk)	TT5B8AX	KTHY_MYCTU	Inhibitor	[1]
Plasmodium Adenylosuccinate synthetase (Malaria Adss)	TTYQ4AE	PURA_PLAFA	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [3] High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12.
• [4] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [5] Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85.