Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJO6GV)

• Drug Name: Abciximab Drug Info
• Synonyms: ReoPro (TN)

Indication

Disease Entry	ICD 11	Status	REF
Acute disease		Approved	[1]
Angina pectoris	BA40	Approved	[2]
Brain ischaemia	8B1Z	Approved	[3]

• Therapeutic Class: Anticoagulants
• Cross-matching ID: TTD Drug ID: DMJO6GV

Molecule-Related Drug Atlas

Drug(s) Targeting Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[6]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[7]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[4]
DMP-444	DMO7BQS	Coronary artery disease	BA80	Phase 3	[8]
99mTc-rBitistatin	DMFAMNH	Pulmonary embolism	JB42	Phase 1/2	[9]
AjvW2	DM6PN4H	Thrombosis	DB61-GB90	Phase 1	[10]
SDZ-GPI-562	DMU9ZGN	Thrombosis	DB61-GB90	Phase 1	[11]
RGD-891	DMVJMF1	Thrombosis	DB61-GB90	Phase 1	[12]
Lefradafiban	DMKZVLH	Angina pectoris	BA40	Phase 1	[13]
XEMILOFIBAN	DMBRYT8	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 3	[14]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[15]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[15]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[18]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[20]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[5]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[5]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[21]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[18]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	TT38RM1	ITA2B_HUMAN; ITB3_HUMAN	Modulator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Integrin alpha-IIb (ITGA2B)	OT4Y17PY	ITA2B_HUMAN	Drug Response	[5]
Integrin beta-3 (ITGB3)	OTWCK1K6	ITB3_HUMAN	Drug Response	[5]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6584).
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• [20] Cholinergic drugs inhibit in?vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor. Platelets. 2011;22(5):390-5. doi: 10.3109/09537104.2010.551304. Epub 2011 Mar 9.
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