Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML5KMT)

Drug Name
Q-27137207 Drug Info
Synonyms LMPR0103890004; 1-Deoxypentalenic acid; 1-deoxypentalenic acid; CHEBI:68832
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10988200
ChEBI ID
CHEBI:68832
TTD Drug ID
DML5KMT
INTEDE Drug ID
DR2675

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 105D7 (cyp105)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [2]
Naringenin DMHAZLM N. A. N. A. Phase 1 [2]
Mevastatin DM1LGKP N. A. N. A. Terminated [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 105D7 (cyp105) Main DME DECV2ME CYP28_STRAW Substrate [2] , [3]

References

1 Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis. J Antibiot (Tokyo). 2011 Jan;64(1):65-71.
2 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
3 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.