Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLNMEA)

Drug Name

Estradiol valerate/dienogest Drug Info

Synonyms

Climodien; Climodiene; Dienogest/estradiol valerate; DNG/E2V; E2V/DNG; Klimodien; Lafamme

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[3]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[4]
Ulipristal	DMBNI20	Contraception	QA21	Approved	[2]
Etonogestrel	DMKA8J4	Contraception	QA21	Approved	[5]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[6]
Segesterone acetate; ethinyl estradiol	DMFEGB0	Contraception	QA21	Approved	[7]
Norgestimate	DMYP4XC	Contraception	QA21	Approved	[5]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[8]
Medroxyprogesterone	DMBGWPH	Solid tumour/cancer	2A00-2F9Z	Approved	[8]
Ethynodiol diacetate	DMZM84R	Contraception	QA21	Approved	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
3	Clinical pipeline report, company report or official report of lipocine.
4	Preclinical experience with two selective progesterone receptor modulators on breast and endometrium. Steroids. 2000 Oct-Nov;65(10-11):733-40.
5	Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7.
6	Focus on anastrozole and breast cancer. Curr Med Res Opin. 2003;19(8):683-8.
7	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
8	Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharm... Steroids. 2008 Feb;73(2):222-31.
9	Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus. Endocrinology. 1977 Jun;100(6):1579-84.