Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMSK9W)

Drug Name

5-(1-Methyl-pyrrolidin-2-yl)-2-phenethyl-pyridine Drug Info

Synonyms

CHEMBL190295; 5-(1-Methyl-pyrrolidin-2-yl)-2-phenethyl-pyridine; SCHEMBL11307517; (+/-)6-(2-Phenylethyl)nicotine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[2]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[2]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[2]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[2]
Levallorphan	DMCOLUP	Narcotic depression	6A7Z	Approved	[3]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[2]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[3]
Pipecuronium	DM5F84A	Spasm	MB47.3	Approved	[3]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[4]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3237-40.
2	Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
3	Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
4	Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6.
5	Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8.