Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMY2S5)

Drug Name

Nitroimidazole Drug Info

Synonyms

Nitroimidazole compounds (infection)

Indication

Disease Entry	ICD 11	Status	REF
Trypanosomiasis	1D51-1F53	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Metabolized By Retro-nitroreductase (rNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AI3-23606	DMHMT49	Trypanosomiasis	1D51-1F53	Phase 1	[3]
Benzoquinone	DMNBA0G	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase B (nfsB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AI3-23606	DMHMT49	Trypanosomiasis	1D51-1F53	Phase 1	[2]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[4]
CL-205086	DMB6XUY	Intestinal amebiasis	1A36	Investigative	[2]
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Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase A (nfsA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ornidazole	DM6QHDJ	Amoebiasis	1A36	Approved	[5]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[5]
AI3-23606	DMHMT49	Trypanosomiasis	1D51-1F53	Phase 1	[2]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[4]
CL-205086	DMB6XUY	Intestinal amebiasis	1A36	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Oxygen-insensitive NADPH nitroreductase A (nfsA)	DEX5D46	NFSA_SALTY	Substrate	[2]
Oxygen-insensitive NADPH nitroreductase B (nfsB)	DEOWDK1	NFSB_SALTY	Substrate	[2]
Retro-nitroreductase (rNR)	DEKVGPX	A0A0H3CM55_ENTCC	Substrate	[3]

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References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8.
3	Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase. Antioxid Redox Signal. 2001 Oct;3(5):747-55.
4	Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact. 2012 Apr 15;197(1):16-22.
5	Identification and characterization of SnrA, an inducible oxygen-insensitive nitroreductase in Salmonella enterica serovar Typhimurium TA1535. Mutat Res. 2002 Oct 31;508(1-2):59-70.