General Information of Drug (ID: DMN4G7U)

Drug Name
1-(2-hydroxy-4-nitrophenyl)-3-phenylurea Drug Info
Synonyms
1-(2-Hydroxy-4-nitrophenyl)-3-phenylurea; 80883-76-7; CHEMBL280711; NSC157449; AC1MUHEY; 1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea; SKampF 83589; GTPL834; SCHEMBL5595180; CTK9A5291; DTXSID00394355; ZINC3936851; BDBM50140794; AKOS024384917; NSC-157449; MCULE-1458670709; NSC 157449; N-(2-hydroxy-4-nitrophenyl)-N'-phenylurea; ST51035446; [(2-hydroxy-4-nitrophenyl)amino]-N-benzamide; N-(2-hydroxy-4-nitrophenyl)-N'-(phenyl); 1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea; SK&F 83589
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3618472
CAS Number
CAS 80883-76-7
TTD Drug ID
DMN4G7U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
Reparixin DMVBA7I Pancreatic islet transplantation failure NE84 Phase 3 [4]
SCH-527123 DMPUAOE Chronic obstructive pulmonary disease CA22 Phase 2 [5]
SX-682 DMHMG6X Melanoma 2C30 Phase 1 [6]
INDOPROFEN DM5QSKN Gout FA25 Withdrawn from market [4]
R-ketoprofen DMHSUQ1 N. A. N. A. Discontinued in Phase 2 [4]
2-(3-Isopropyl-phenyl)-propionic acid DMUOWNE Discovery agent N.A. Investigative [4]
2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid DMWIUR0 Discovery agent N.A. Investigative [4]
(R)-2-(4-Isobutyl-phenyl)-propionamide DMBQ0PR Discovery agent N.A. Investigative [4]
(R)-N-Hydroxy-2-(4-isobutyl-phenyl)-propionamide DMWRIQG Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [4]
Clotrimazole DMMFCIH Cutaneous candidiasis 1F23.14 Approved [7]
Reparixin DMVBA7I Pancreatic islet transplantation failure NE84 Phase 3 [4]
SCH-527123 DMPUAOE Chronic obstructive pulmonary disease CA22 Phase 2 [8]
SB-265610 DM8TKG5 Asthma CA23 Phase 2 [9]
AZD-5069 DM3JSFK Asthma CA23 Phase 2 [10]
PS-938285 DMHZIFJ Chronic obstructive pulmonary disease CA22 Phase 2 [11]
GSK1325756 DMA6RBF Chronic obstructive pulmonary disease CA22 Phase 2 [12]
SB-656933 DMCY785 Chronic obstructive pulmonary disease CA22 Phase 2 [13]
RIST4721 DMA3DKO Hidradenitis suppurativa ED92.0 Phase 2 [14]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-X-C chemokine receptor type 1 (CXCR1) TTMWT8Z CXCR1_HUMAN Inhibitor [2]
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Inhibitor [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 834).
2 Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11;47(6):1319-21.
3 Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273(17):10095-8.
4 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.
7 Mode of action of clotrimazole: implications for therapy. Am J Obstet Gynecol. 1985 Aug 1;152(7 Pt 2):939-44.
8 CXCR2 Antagonist MK-7123.A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med.2015 May 1;191(9):1001-11.
9 Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
10 Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist. J Pharmacol Exp Ther. 2015 May;353(2):340-50.
11 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
12 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
13 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
14 A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.